[1]王芬燕,索艳晖,陈秀梅,等.血清高迁移率族蛋白质B1、组蛋白脱乙酰酶3、抵抗素水平与踝关节周围损伤患者骨髓水肿和疼痛程度的关系[J].中医正骨,2026,38(03):40-43,58.
　WANG Fenyan,SUO Yanhui,CHEN Xiumei,et al.Relationship of serum high mobility group protein B1,histone deacetylase 3,and resistin levels with bone marrow edema and pain severity in patients with periankle injuries[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2026,38(03):40-43,58.
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血清高迁移率族蛋白质B1、组蛋白脱乙酰酶3、抵抗素水平与踝关节周围损伤患者骨髓水肿和疼痛程度的关系()

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第38卷
期数:
2026年03期
页码:
40-43,58
栏目:
临床研究
出版日期:
2026-03-20

文章信息/Info

Title:
Relationship of serum high mobility group protein B1,histone deacetylase 3,and resistin levels with bone marrow edema and pain severity in patients with periankle injuries
作者:
王芬燕; 索艳晖; 陈秀梅; 冯旭冉; 陈俊霖; 谷佩峰
(邯郸市中心医院,河北 邯郸 056002)
Author(s):
WANG Fenyan; SUO Yanhui; CHEN Xiumei; FENG Xuran; CHEN Junlin; GU Peifeng
Handan Central Hospital,Handan 056002,Hebei,China
关键词:
踝损伤;  HMGB1蛋白;  组蛋白脱乙酰基酶类;  抵抗素;  疼痛;  骨髓;  水肿
Keywords:
ankle injuries;  HMGB1 protein;  histone deacetylases;  resistin;  pain;  bone marrow;  edema
摘要:
目的:分析血清高迁移率族蛋白质B1(high mobility group protein B1,HMGB1)、组蛋白脱乙酰酶3(histone deacetylase 3,HDAC3)、抵抗素水平与踝关节周围损伤患者骨髓水肿和疼痛程度的关系。方法:180例踝关节周围损伤患者,根据MRI检查有无骨髓水肿,分为骨髓水肿组和无骨髓水肿组。采用ELISA法检测2组患者血清HMGB1、HDAC3、抵抗素水平,评价2组患者的疼痛程度,根据MRI矢状面上T2WI脂肪抑制序列高信号区确定骨髓水肿组患者的骨髓水肿范围。分析血清HMGB1、HDAC3、抵抗素水平与骨髓水肿的关系及其与骨髓水肿范围和疼痛程度的相关性。结果:骨髓水肿组血清HMGB1、HDAC3、抵抗素水平均高于无骨髓水肿组(t=10.518,P=0.000; t=8.213,P=0.000; t=10.497,P=0.000)。骨髓水肿组骨髓水肿范围(75.67±18.88)mm2,重度疼痛33例、中度疼痛45例、轻度疼痛12例; 无骨髓水肿组,重度疼痛9例、中度疼痛42例、轻度疼痛39例; 骨髓水肿组的疼痛程度重于无骨髓水肿组(Z=-5.287,P=0.000)。多因素Logistic回归分析结果显示,血清HMGB1、HDAC3、抵抗素水平均为踝关节周围骨挫伤骨髓水肿的危险因素[β=1.153,P=0.000,OR=3.169(2.027,4.954); β=1.266,P=0.000,OR=3.548(2.070,6.082); β=1.006,P=0.000,OR=2.735(1.649,4.535)]。相关性分析结果显示,骨髓水肿患者血清HMGB1、HDAC3、抵抗素水平与骨髓水肿范围及疼痛程度均呈强正相关(r=0.726,P=0.000; r=0.779,P=0.000; r=0.758,P=0.000; rs=0.803,P=0.000; rs=0.762,P=0.000; rs=0.784,P=0.000)。无骨髓水肿患者血清HMGB1、HDAC3、抵抗素水平与疼痛程度呈弱正相关(rs=0.215,P=0.042; rs=0.208,P=0.048; rs=0.221,P=0.037)。结论:血清HMGB1、HDAC3、抵抗素水平是踝关节周围损伤骨髓水肿的危险因素,且其水平越高患者骨髓水肿范围越大、疼痛越严重。
Abstract:
Objective:To analyze the relationship of serum high mobility group protein B1(HMGB1),histone deacetylase 3(HDAC3),and resistin levels with bone marrow edema(BME)and pain severity in patients with periankle injuries.Methods:One hundred and eighty patients with periankle injuries were enrolled and divided into a BME group and a non-BME group based on the presence or absence of BME on MRI.The serum levels of HMGB1,HDAC3,and resistin in both groups were detected using ELISA,and the pain levels were assessed.The extent of BME in the BME group was determined by the area of high-signal intensity on fat-suppressed T2-weighted images in the sagittal plane.The relationship between serum HMGB1,HDAC3,and resistin levels and BME,as well as their correlation with the extent of BME and pain severity,were analyzed.Results:The serum levels of HMGB1,HDAC3,and resistin were significantly higher in BME group compared to non-BME group(t=10.518,P=0.000; t=8.213,P=0.000; t=10.497,P=0.000).The extent of BME in the BME group was(75.67±18.88)mm2,with 33 cases of severe pain,45 cases of moderate pain,and 12 cases of mild pain.In the non-BME group,there were 9 cases of severe pain,42 cases of moderate pain,and 39 cases of mild pain.The pain severity was significantly greater in BME group compared to non-BME group(Z=-5.287,P=0.000).Multivariate logistic regression analysis identified serum HMGB1,HDAC3,and resistin levels as risk factors for BME following periankle bone contusions(β=1.153,P=0.000,OR=3.169(2.027,4.954); β=1.266,P=0.000,OR=3.548(2.070,6.082); β=1.006,P=0.000,OR=2.735(1.649,4.535)).Correlation analysis revealed that,in patients with BME,serum HMGB1,HDAC3,and resistin levels were all strongly positively correlated with both the extent of BME and the degree of pain(r=0.726,P=0.000; r=0.779,P=0.000; r=0.758,P=0.000; rs=0.803,P=0.000; rs=0.762,P=0.000; rs=0.784,P=0.000).While in patients without BME,these serum markers were all weakly positively correlated with the degree of pain(rs=0.215,P=0.042; rs=0.208,P=0.048; rs=0.221,P=0.037).Conclusion:Elevated serum levels of HMGB1,HDAC3,and resistin are risk factors for BME in patients with periankle injuries,and higher levels of these biomarkers are associated with a larger extent of BME and greater pain severity.

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备注/Memo

备注/Memo:
通信作者:王芬燕 E-mail:452993398@qq.com
(收稿日期:2025-06-05 本文编辑:杨雅)
更新日期/Last Update: 2026-03-20