[1]张云辉,吴俊德,陈兆军,等.印度刺猬蛋白调控关节软骨代谢的研究进展[J].中医正骨,2025,37(04):55-60.
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印度刺猬蛋白调控关节软骨代谢的研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第37卷
期数:
2025年04期
页码:
55-60
栏目:
综述
出版日期:
2025-04-20

文章信息/Info

作者:
张云辉吴俊德陈兆军潘旭月魏芳远
北京中医药大学第三附属医院,北京 100029
关键词:
骨关节炎 软骨关节 软骨细胞 代谢 印度刺猬蛋白 综述
摘要:
骨关节炎(osteoarthritis,OA)是一种常见的退行性关节疾病,其特征是关节软骨逐渐退化和功能丧失。印度刺猬蛋白(Indian hedgehog,IHH)作为Hedgehog信号通路的核心配体,通过复杂的信号网络调控软骨细胞增殖、分化及凋亡的动态平衡,在关节软骨发育与稳态维持过程中发挥关键作用。近年来,寻找与OA诊断和治疗相关的生物标志物及潜在治疗靶点一直是一个热门的研究方向,而多项研究已证实IHH与关节软骨代谢高度相关。本文概述了IHH,对IHH调控关节软骨代谢的信号通路、作用机制及作为潜在治疗靶点的研究进展进行了综述。

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备注/Memo

备注/Memo:
基金项目:北京市自然科学基金面上项目(7232026)
通讯作者:魏芳远 E-mail:footwfy@126.com
更新日期/Last Update: 1900-01-01