[1]罗淦,汤样华,康仪,等.骨关节炎相关信号通路的研究进展[J].中医正骨,2019,31(05):31-37.
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骨关节炎相关信号通路的研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期数:
2019年05期
页码:
31-37
栏目:
综 述
出版日期:
2019-05-20

文章信息/Info

作者:
罗淦; 汤样华; 康仪; 辛大伟; 熊振飞; 徐灿达; 岳振双; 曾林如
(浙江中医药大学附属江南医院,浙江 杭州 311201)
关键词:
骨关节炎;  p38丝裂原活化蛋白激酶类;  c-Jun氨基末端激酶;  Toll样受体;  蛋白酪氨酸激酶类;  STAT3转录因子;  趋化因子CXCL12;  受体;  CXCR4;  受体; Notch;  Wnt信号通路;  转化生长因子β;  骨保护素;  核因子κB受体活化因子;  综述
摘要:
骨关节炎是一种严重影响患者生活质量的关节退行性疾病,其病因及发病机制尚不完全清楚。目前,国内外大量研究已证实骨关节炎的病理变化过程与众多信号通路有密切联系,其中部分信号通路与介导骨关节炎软骨破坏及调控软骨细胞凋亡有关,如p38丝裂原活化蛋白激酶、c-Jun氨基末端激酶、Toll样受体等信号通路等; 还有部分信号通路对骨关节炎软骨细胞增殖和凋亡具有双重调节作用,如细胞外调节蛋白激酶、Notch、Wnt等信号通路。本文就骨关节炎相关信号通路的研究进展进行了综述。

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更新日期/Last Update: 2019-05-20