[1]吴鑫杰,谭明生,移平.NOD样受体蛋白3炎性小体在创伤性脊髓损伤中的作用[J].中医正骨,2019,31(02):31-35.
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NOD样受体蛋白3炎性小体在创伤性脊髓损伤中的作用()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期数:
2019年02期
页码:
31-35
栏目:
综 述
出版日期:
2019-02-20

文章信息/Info

作者:
吴鑫杰谭明生移平
(中日友好医院,北京 100029)
关键词:
脊髓损伤 NLRP3 焦亡 综述
摘要:
NOD样受体蛋白3(NOD-like receptor protein 3,NLRP3)炎性小体是介导固有免疫反应的重要蛋白,在创伤性脊髓损伤的第2个病理阶段中发挥着重要作用。炎性小体的活化被认为是半胱氨酸蛋白水解酶-1依赖的焦亡途径的一个关键因素,参与半胱氨酸蛋白水解酶-1的活化并将白细胞介素18和白细胞介素1β前体转化为活性形式,导致脊髓神经细胞死亡。本文对NLRP3炎性小体的结构及NLRP3炎性小体在创伤性脊髓损伤中的作用机制、激活途径及其调节以及NLRP3炎性小体在创伤性脊髓损伤治疗中的作用进行了综述。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(81873141); 北京市科委首都临床特色应用研究专项课题(Z161100000516009) 通讯作者:移平 E-mail:dryiping_123@163.com(收稿日期:2019-01-22 本文编辑:李晓乐)
更新日期/Last Update: 2019-02-20