[1]吴震,童培建,张培祥,等.张氏膝痛方联合塞来昔布胶囊口服治疗湿热阻络型膝关节滑膜炎的临床研究[J].中医正骨,2017,29(04):13-15,22.
　WU Zhen,TONG Peijian,ZHANG Peixiang,et al.A clinical study of oral application of Zhang's Xitong Fang(张氏膝痛方)and celebrex capsules for treatment of gonarthromeningitis with DAMPNESS-HEAT BLOCK COLLATERALS syndrome[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2017,29(04):13-15,22.
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张氏膝痛方联合塞来昔布胶囊口服治疗湿热阻络型膝关节滑膜炎的临床研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第29卷
期数:
2017年04期
页码:
13-15,22
栏目:
临床研究
出版日期:
2017-04-20

文章信息/Info

Title:
A clinical study of oral application of Zhang's Xitong Fang(张氏膝痛方)and celebrex capsules for treatment of gonarthromeningitis with DAMPNESS-HEAT BLOCK COLLATERALS syndrome
作者:
吴震1; 童培建2; 张培祥3; 张晓文3
1.浙江中医药大学,浙江 杭州 310053; 2.浙江中医药大学附属第一医院, 浙江 杭州 310006; 3.浙江省立同德医院,浙江 杭州 310012
Author(s):
WU Zhen1; TONG Peijian2; ZHANG Peixiang3; ZHANG Xiaowen3
1.Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China 2.The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,Zhejiang,China 3.Tongde Hospital of Zhejiang Province, Hangzhou 310012,Zhejiang,China
关键词:
滑膜炎;  膝损伤;  张氏膝痛方;  塞来昔布
Keywords:
Key words synovitis;  knee injuries;  Zhang's Xitong Fang;  celebrex
摘要:
目的:探讨张氏膝痛方联合塞来昔布胶囊口服治疗湿热阻络型膝关节滑膜炎的临床疗效和安全性。方法:2013年1月至2016年1月,选择湿热阻络型膝关节滑膜炎患者100例,随机分为2组,每组50例。分别采用张氏膝痛方联合塞来昔布胶囊口服治疗和单纯塞来昔布胶囊口服治疗。4周为1个疗程,共服1个疗程。治疗前后,依据Lysholm膝关节评分标准对2组患者膝关节进行评分,根据治疗后Lysholm膝关节评分增加的程度评价疗效,并观察服药后不良反应发生情况。结果:治疗前,2组患者Lysholm膝关节评分比较,差异无统计学意义[(58.14±10.73)分,(57.72±10.97)分; t=0.195,P=0.846)]; 治疗后,2组患者Lysholm膝关节评分均增加(t=-14.020,P=0.000; t=-9.545,P=0.000); 且膝痛方联合塞来昔布组Lysholm膝关节评分高于塞来昔布组[(86.14±9.17)分,(75.30±8.31)分; t=6.194,P=0.000]。根据治疗后Lysholm膝关节评分增加的程度评价疗效,膝痛方联合塞来昔布组,显效21例、有效22例、好转5例、无效2例; 塞来昔布组,显效9例、有效22例、好转10例、无效9例; 膝痛方联合塞来昔布组临床疗效优于塞来昔布组(Z=-3.261,P=0.001)。2组各出现胃肠道不良反应1例,经口服奥美拉唑胶囊治疗后症状消失; 均无肝肾功能障碍等严重不良反应发生。2组患者不良反应发生率比较,差异无统计学意义(χ2=0.000,P=1.000)。结论:张氏膝痛方联合塞来昔布胶囊口服治疗湿热阻络型膝关节滑膜炎,疗效优于单纯口服塞来昔布胶囊,且并未增加不良反应发生的风险。
Abstract:
ABSTRACT Objective:To explore the clinical curative effects and safety of oral application of Zhang's Xitong Fang(张氏膝痛方,ZSXTF)and celebrex capsules for treatment of gonarthromeningitis with DAMPNESS-HEAT BLOCK COLLATERALS syndrome.Methods:From January 2013 to January 2016,one hundred patients with gonarthromeningitis with DAMPNESS-HEAT BLOCK COLLATERALS syndrome were selected and randomly divided into 2 groups,50 cases in each group.The patients were treated with combination therapy of application of ZSXTF and celebrex capsules(group A)and monotherapy of oral application of celebrex capsules(group B)respectively for consecutive 4 weeks.The knee joints were scored by using Lysholm knee joint scoring standards before and after the treatment in both of the 2 groups,and the curative effects were evaluated according to the increasing degree of posttreatment Lysholm knee scores.The incidence rate of adverse reactions was also observed.Results:There was no statistical difference in Lysholm knee joint scores between the 2 groups before the treatment(58.14+/-10.73 vs 57.72+/-10.97 points,t=0.195,P=0.846).The Lysholm knee joint scores increased in both of the 2 groups after the treatment(t=-14.020,P=0.000; t=-9.545,P=0.000).The Lysholm knee joint scores were higher in group A compared to group B(86.14+/-9.17 vs 75.30+/-8.31 points,t=6.194,P=0.000).Twenty-one patients obtained an excellent result,22 good,5 fair and 2 poor in group A; while 9 patients obtained an excellent result,22 good,10 fair and 9 poor in group B.The group----------------------------------------------- A surpassed the group B in the total curative effect(Z=-3.261,P=0.001).The gastrointestinal adverse reactions were found in the 2 groups(1 case in each group),and the symptoms disappeared after oral application of omeprazole capsules.No severe adverse reaction such as hepatorenal disfunction were found in the 2 groups.There was no statistical difference in the incidence rate of adverse reactions between the 2 groups(χ2=0.000,P=1.000).Conclusion:The curative effect of combination therapy of oral application of ZSXTF and celebrex capsules is better than that of monotherapy of oral application of celebrex capsules in the treatment of gonarthromeningitis with DAMPNESS-HEAT BLOCK COLLATERALS syndrome,and it do not increase the risk of adverse reactions.

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[2]郑昱新,詹红生,莫文,等.滑膜炎颗粒治疗膝关节滑膜炎湿热阻络证的随机、 双盲、安慰剂对照、多中心临床研究[J].中医正骨,2015,27(12):29.
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备注/Memo

备注/Memo:
基金项目:全国名老中医药专家传承工作室建设项目(国中医药人教发[2014]20号) 通讯作者:吴震 E-mail:wzonline78@hotmail.com
更新日期/Last Update: 1900-01-01