[1]焦 锋.益肾活血中药对股骨转子间骨折患者术后血清碱性磷酸酶和血清总钙浓度的影响[J].中医正骨,2016,28(04):16-18.
　JIAO Feng.Effect of Yishen Huoxue(益肾活血)traditional Chinese medicine on postoperative serum concentrations of alkaline phosphatase and total calcium in patients with intertrochanteric fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(04):16-18.
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益肾活血中药对股骨转子间骨折患者术后血清碱性磷酸酶和 血清总钙浓度的影响()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第28卷
期数:
2016年04期
页码:
16-18
栏目:
临床研究
出版日期:
2016-04-20

文章信息/Info

Title:
Effect of Yishen Huoxue(益肾活血)traditional Chinese medicine on postoperative serum concentrations of alkaline phosphatase and total calcium in patients with intertrochanteric fractures
作者:
焦 锋
广东省广州市中西医结合医院,广东 广州 510800
Author(s):
JIAO Feng
Guangzhou combinational hospital of traditional Chinese medicine and Western medicine,Guangzhou 510800,Guangdong,China
关键词:
碱性磷酸酶;  钙;  骨折愈合;  中药疗法;  益肾活血;  髋骨折;  治疗; 临床研究性
Keywords:
alkaline phosphatase;  calcium;  fracture healing;  drug therapy(TCD);  Yishen Huoxue;  hip fractures;  therapies; investigational
摘要:
目的:观察益肾活血中药对股骨转子间骨折患者术后血清碱性磷酸酶和血清总钙浓度的影响。方法:选取60例股骨转子间骨折患者,随机分为中药组和常规组,每组30例。所有患者均由同一组医师完成闭合复位股骨近端防旋髓内钉内固定手术,术后常规进行抗感染、抗凝及营养支持治疗。术后中药组患者在常规治疗的基础上口服益肾活血中药,连续服用14 d。分别于术后即刻和术后14 d抽静脉血测定患者血清碱性磷酸酶和血清总钙浓度。结果:术后即刻2组患者血清碱性磷酸酶和血清总钙浓度比较,组间差异均无统计学意义(t=0.196,P=0.846; t=0.407,P=0.685)。术后14 d时中药组的血清碱性磷酸酶浓度增高[(90.62±12.19)mmol·L-1,(105.40±11.63)mmol·L-1,t=4.805,P=0.000]; 常规组与术后即刻相比,差异无统计学意义[(91.27±13.52)mmol·L-1,(94.60±11.10)mmol·L-1,t=1.043,P=0.297]; 术后14 d时中药组血清碱性磷酸酶浓度高于常规组(t=3.679,P=0.001)。术后14 d时2组患者的血清总钙浓度均增高[(2.20±0.10)mmol·L-1,(2.29±0.10)mmol·L-1,t=3.486,P=0.000;(2.19±0.09)mmol·L-1,(2.27±0.12)mmol·L-1,t=2.292,P=0.005]; 术后14 d时2组患者的血清总钙浓度比较,差异无统计学意义(t=0.701,P=0.486)。结论:口服益肾活血中药可提高股骨转子间骨折患者术后血清碱性磷酸酶浓度,但对血清总钙浓度无明显影响。
Abstract:
Objective:To observe the effect of Yishen Huoxue(益肾活血 YSHX)traditional Chinese medicine(TCM)on postoperative serum concentrations of alkaline phosphatase(AKP)and total calcium(TC)in patients with intertrochanteric fractures.Methods:Sixty patients with intertrochanteric fractures were selected and randomly divided into TCD group and conventional group,30 cases in each group.Closed reduction and proximal femoral nail anti-rotation internal fixation were performed in both of the 2 groups by the same group of surgeons.After the surgery,all of the patients were treated conventionally with anti-infective,anticoagulants and nutritional support.Moreover,the patients in TCD group were treated with oral application of YSHX TCM for consecutive 14 days.The serum concentrations of AKP and TC were measured after surgery immediately and at 14 days after surgery respectively.Results:There was no statistical difference in serum concentrations of AKP and TC between the 2 groups immediately post-operatively(t=0.196,P=0.846; t=0.407,P=0.685).The serum AKP concentrations increased in TCD group at 14 days after surgery(90.62+/-12.19 vs 105.40+/-11.63 mmol/l,t=4.805,P=0.000),and there was no statistical difference in serum AKP concentrations between the 2 timepoints in conventional group(91.27+/-13.52 vs 94.60+/-11.10 mmol/l,t=1.043,P=0.297).The serum AKP concentrations were higher in TCD group compared to conventional group at 14 days after surgery(t=3.679,P=0.001).The serum TC concentrations increased in both of the 2 groups at 14 days after surgery(2.20+/-0.10 vs 2.29+/-0.10 mmol/l,t=3.486,P=0.000; 2.19+/-0.09 vs 2.27+/-0.12 mmol/l,t=2.292,P=0.005).There was no statistical difference in serum TC concentrations between the 2 groups at 14 days after surgery(t=0.701,P=0.486).Conclusion:Oral application of YSHX TCM can raise postoperative serum AKP concentrations in patients with intertrochanteric fractures,while it has no obvious effect on serum TC concentrations.

参考文献/References:

[1] 李畅居,辛俊平,邓淑铃.骨质疏松的中医药干预进展[J].中国热带医学,2006,6(8):1468-1470.
[2] 蒋铭,徐锋,孙斌峰,等.股骨近端防旋髓内钉内固定配合中药内服治疗老年股骨转子间骨折[J].中医正骨,2014,26(7):17-19.
[3] 国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:170.
[4] 杨锋,李小群,李彦民,等.活血化瘀法对骨折早期基因表达谱的影响[J].辽宁中医杂志,2013,40(6):1246-1249.
[5] 张镝,贾志杰,田永利,等.补肾中药有效成分对大鼠骨损伤愈合及血液流变学的影响[J].中国组织工程研究与临床康复,2011,15(24):4545-4548.
[6] 田敏,孙磊,陈晓亮,等.骨质疏松症大鼠骨诱导能力改变的研究[J].中华老年医学杂志,2004,23(6):57-60.
[7] Anderson HC,Sipe JB,Hessle L,et al.Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice[J].Am J Pathol,2004,164(3):841-847.
[8] 洪宁,胡信雷,耿春辉.活血通络中药复方对家兔骨折后血清碱性磷酸酶、钙、磷的影响[J].淮海医药,2007,25(5):420-422.

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更新日期/Last Update: 2016-08-30