[1]陈俊杰,庄汝杰,范续,等.膝骨关节炎软骨下炎症面积与关节液中白细胞介素-1含量的相关性研究[J].中医正骨,2016,28(04):9-11,15.
　CHEN Junjie,ZHUANG Rujie,FAN Xu,et al.Study on the correlations between subchondral inflammation areas and interleukin-1 contents in joint fluid in patients with knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(04):9-11,15.
点击复制

膝骨关节炎软骨下炎症面积与关节液中白细胞介素-1含量的相关性研究()
分享到：

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第28卷
期数:
2016年04期
页码:
9-11,15
栏目:
临床研究
出版日期:
2016-04-20

文章信息/Info

Title:
Study on the correlations between subchondral inflammation areas and interleukin-1 contents in joint fluid in patients with knee osteoarthritis
作者:
陈俊杰1; 庄汝杰2; 范续1; 张娅1
1.浙江中医药大学,浙江 杭州 310053;
2.浙江省中医院,浙江 杭州 310006
Author(s):
CHEN Junjie1; ZHUANG Rujie2; FAN Xu1; ZHANG Ya1
1.Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China
2.Zhejiang Provincial Hospital of TCM,Hangzhou 310006,Zhejiang,China
关键词:
骨关节炎; 膝;  白细胞介素-1;  滑液;  软骨下炎症面积;  相关分析;  磁共振成像
Keywords:
osteoarthritis; knee;  interleukin-1;  synovial fluid;  subchondral inflammation area;  correlation analysis;  magnetic resonance imaging
摘要:
目的:探讨膝骨关节炎软骨下炎症面积与关节液中白细胞介素-1含量的相关性。方法:2014年6—12月,对30例膝骨关节炎患者行患肢膝关节矢状面超短回波时间(ultrashort echo time,UTE)脉冲序列MRI检查,测量膝关节软骨下炎症面积,并对其与关节液中白细胞介素-1含量的相关性进行分析。结果:本组30例,患肢膝关节MRI检查UTE序列上均可见软骨下高信号区,其中髌骨软骨下高信号区16例,股骨软骨下高信号区8例,胫骨软骨下高信号区6例。软骨下炎症面积(140.61±61.65)mm2,关节液中白细胞介素-1含量(0.170±0.102)pg·mL-1,两者呈正相关(r=0.472,P=0.008)。结论:膝骨关节炎患者膝关节软骨下炎症面积和关节液中白细胞介素-1含量呈正相关; 膝关节软骨下炎症面积越大,关节液中白细胞介素-1含量越高。
Abstract:
Objective:To explore the correlations between subchondral inflammation areas and interleukin-1(IL-1)contents in joint fluid in patients with knee osteoarthritis(KOA).Methods:The ultrashort echo time(UTE)pulse train MRI examination in sagittal plane were performed upon the affected limbs of 30 patients with KOA from June 2014 to December 2014,then the subchondral inflammation areas of knee joint were measured and the correlations between subchondral inflammation areas and IL-1 contents in joint fluid were analyzed.Results:The subchondral high-intensity zones were found in UTE pulse train MRI images of knee joints in all of the 30 patients,16 cases in patella,8 in femur and 6 in tibia.The subchondral inflammation areas(140.61+/-61.65 mm(2))were positively correlated with IL-1 contents(0.170+/-0.102 pg/ml)in joint fluid(r=0.472,P=0.008).Conclusion:The knee-joint subchondral inflammation areas are positively correlated with IL-1 contents in joint fluid in patients with KOA.The greater the knee-joint subchondral inflammation areas are,the higher the IL-1 contents in joint fluid are.

参考文献/References:

[1] Felson DT.An update on the pathogenesis and epidemiology of osteoarthritis[J].Radiol Clin North Am,2004,42(1):1-9.
[2] Felson DT,Zhang Y.An update on the epidemiology of knee and hip osteoarthritis with a view to prevention[J].Arthritis Rheum,1998,41(8):1343-1355.
[3] 邱贵兴.骨关节炎流行病学和病因学新进展[J].继续医学教育,2005,19(7):68-69.
[4] 李敏,梁翼,吴晓惠,等.伴骨髓水肿的膝骨关节炎患者白细胞介素-1β白细胞介素-6肿瘤坏死因子-α的相关性研究[J].中华风湿病学杂志,2012,16(2):107-111.
[5] 王洪,张青松,杨述华,等.IL-1RⅠ IL-1RⅡ IL-1RAcP在骨关节炎滑膜中的表达及其生物学意义[J].中华风湿病学杂志,2006,10(8):470-473.
[6] Amir G,Goldfarb AW,Nyska M,et al.2-Butoxyethanol model of haemolysis and disseminated thrombosis in female rats: a preliminary study of the vascular mechanism of osteoarthritis in the temporomandibular joint[J].Br J Oral Maxillofac Surg,2011,49(1):21-25.
[7] Pfander D,Körtje D,Zimmermann R,et al.Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints[J].Ann Rheum Dis,2001,60(11):1070-1073.
[8] 王亮,陈祁青,童培建,等.膝关节骨性关节炎早期诊断的临床特征分析[J].中国骨与关节损伤杂志,2015,30(2):161-163.
[9] Robson MD,Bydder GM.Clinical ultrashort echo time imaging of bone and other connective tissues[J].NMR Biomed,2006,19(7):765-780.
[10] 马立恒,陈应明,张朝晖,等.正常兔膝关节的三维UTE动态增强MRI实验研究[J].放射学实践,2014,29(7):766-769.
[11] Du J,Takahashi AM, Bae WC,et al. Dual inversion recovery, ultrashort echo time(DIR UTE)imaging: creating high contrast for short-T(2)species[J].Magn Reson Med,2010,63(2):447-455.
[12] Du J,Hamilton G,Takahashi A,et al.Ultrashort echo time spectroscopic imaging(UTESI)of cortical bone[J].Magn Reson Med,2007,58(5):1001-1009.
[13] Qian Y,Williams AA,Chu CR,et al.Repeatability of ultrashort echo time-based two-component T2 measurements on cartilages in human knee at 3T[J].Magn Reson Med,2013,69(6):1564-1572.
[14] 马少云,陈利新,曹建斌,等.膝骨性关节炎中医证型与一氧化氮、白介素1β、转化生长因子β1的关系研究[J].中医正骨,2008,20(4):3-4.
[15] 余丹丹.骨性关节炎实验研究进展[J].中医正骨,2000,12(12):50-52.
[16] Shinmei M,Masuda K,Kikuchi T,et al.Interleukin 1,tumor necrosis factor and interleukin 6 as mediators of cartilage destruction[J].Semin Arthritis Rheum,1989,18(3 Suppl 1):27-32.

相似文献/References:

[1]樊庆阳,任凯晶.定制3D打印切模辅助全膝关节置换术治疗 膝骨关节炎合并股骨干骨折畸形愈合[J].中医正骨,2015,27(11):37.
[2]刘晓雅,孙永强,刘国杰.主动快速康复锻炼对全膝关节置换术后关节活动度的影响[J].中医正骨,2015,27(09):73.
[3]郑春松,叶蕻芝,李西海,等.透骨消痛胶囊中补肾柔肝药和活血祛风药治疗 骨关节炎作用方式的计算机模拟比较[J].中医正骨,2015,27(07):6.
　ZHENG Chunsong,YE Hongzhi,LI Xihai,et al.Comparison of the mode of action of Bushen Rougan(补肾柔肝)drugs versus Huoxue Qufeng(活血祛风)drugs contained in Tougu Xiaotong Jiaonang(透骨消痛胶囊)for the treatment of osteoarthritis:A computer simulation study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(04):6.
[4]宋兵华,孙俊英,倪增良,等.全膝关节置换术前CT测量股骨后髁角的临床意义[J].中医正骨,2015,27(07):38.
[5]郑春松,叶蕻芝,李西海,等.独活寄生汤含药血清对白细胞介素1β诱导的 退变关节软骨细胞中基质金属蛋白酶 和环氧化酶2表达的影响[J].中医正骨,2015,27(12):1.
　ZHENG Chunsong,YE Hongzhi,LI Xihai,et al.Impact of Duhuo Jisheng Tang(独活寄生汤)medicated serum on expression of matrix metalloproteinase and cyclooxygenase 2 in degenerative articular chondrocytes induced by interleukin-1 beta[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(04):1.
[6]王金良,孙京涛,李玲,等.骨水泥联合螺钉修复全膝关节置换术中 胫骨平台内侧骨缺损[J].中医正骨,2015,27(12):55.
[7]冯荣,王平,李炳奇,等.铍针刺络拔罐结合中药口服治疗膝骨关节炎合并 原发性血小板增多症1例[J].中医正骨,2015,27(12):73.
[8]蔡云仙.围手术期耳穴按压联合平衡针疗法 在全膝关节置换术后镇痛中的应用[J].中医正骨,2015,27(06):41.
[9]张荣,王健.人工全膝关节置换术的围手术期心理护理[J].中医正骨,2015,27(05):77.
[10]喻长纯,杨明路,王战朝.不同手术方式治疗胫骨平台骨折畸形愈合的体会[J].中医正骨,2015,27(03):37.
[11]孟维娜,明立功,王新德,等.关节镜下清理联合腓骨近1/3段截骨治疗膝骨关节炎[J].中医正骨,2015,27(11):40.
[12]明立功,孟维娜,王新德,等.腓骨近端截骨治疗内侧间室膝骨关节炎的近期疗效观察[J].中医正骨,2015,27(10):25.
[13]张杰,王人彦,张玉柱.膝骨关节炎的治疗进展[J].中医正骨,2015,27(10):68.
[14]梁朝,蔡静怡,闫立,等.针刀疗法改善膝骨关节炎早期疼痛症状的疗效评价[J].中医正骨,2015,27(09):9.
　LIANG Zhao,CAI Jingyi,YAN Li,et al.Evaluation of the curative effect of needle-knife therapy for relieving knee pain in patients with early knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(04):9.
[15]王建武,党建军,李强,等.四联疗法治疗膝骨关节炎[J].中医正骨,2015,27(08):44.
[16]刘红娟,郭会利,郭树农.云克联合中药治疗膝骨关节炎的护理[J].中医正骨,2015,27(08):75.
[17]陈卫衡.探索建立系统的膝骨关节炎中医临床科研范式 和理论体系[J].中医正骨,2015,27(07):1.
[18]帅波,沈霖,杨艳萍,等.加味青娥丸治疗膝骨关节炎的作用机制研究[J].中医正骨,2015,27(07):15.
　SHUAI Bo,SHEN Lin,YANG Yanping,et al.Study on the mechanism of action of Jiawei Qing'e Wan(加味青娥丸)for the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(04):15.
[19]梅其杰,袁长深,段戡,等.壮药骨痹方烫熨联合运动疗法治疗膝骨关节炎的临床研究[J].中医正骨,2015,27(07):27.
　MEI Qijie,YUAN Changshen,DUAN Kan,et al.Clinical study of the curative effect of hot compressing and rubbing with packet of Gubi Fang(骨痹方)combined with exercise therapy in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(04):27.
[20]王丹辉,张燕,刘丽娟,等.重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白 关节腔注射联合中药薰洗治疗膝骨关节炎的临床研究[J].中医正骨,2015,27(07):31.
　WANG Danhui,ZHANG Yan,LIU Lijuan,et al.Clinical study on intra-articular injection of TypeⅡrecombinant human tumor necrosis factor receptor-Fc fusion protein combined with Chinese herbal steaming and washing therapy for treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(04):31.

备注/Memo

备注/Memo:
基金项目:浙江省医药卫生科技计划项目(2013KYB184),浙江省重点科技创新团队项目(2011R50022-04),浙江省重大科技专项计划项目(2014C03038)
通讯作者:庄汝杰 E-mail:rujiezhuang@163.com
更新日期/Last Update: 2016-08-30