[1]谭福柱,张乐鑫,任树军.针刺配合口服骨力胶囊治疗膝关节骨性关节炎的 临床研究[J].中医正骨,2015,27(01):20-22.
　TAN Fuzhu,ZHANG Lexin,REN Shujun.Clinical study on acupuncture therapy combined with oral application of Guli Jiaonang(骨力胶囊)for treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(01):20-22.
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针刺配合口服骨力胶囊治疗膝关节骨性关节炎的 临床研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第27卷
期数:
2015年01期
页码:
20-22
栏目:
临床研究
出版日期:
2015-01-15

文章信息/Info

Title:
Clinical study on acupuncture therapy combined with oral application of Guli Jiaonang(骨力胶囊)for treatment of knee osteoarthritis
作者:
谭福柱1; 张乐鑫2; 任树军1
1.黑龙江中医药大学附属第一医院,黑龙江 哈尔滨 150040;
2.黑龙江中医药大学,黑龙江 哈尔滨 150040
Author(s):
TAN Fuzhu1; ZHANG Lexin2; REN Shujun1
1.The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Haerbin 150040,Heilongjiang,China
2.Heilongjiang University of Traditional Chinese Medicine,Haerbin 150040,Heilongjiang,China
关键词:
骨关节炎; 膝;  针刺疗法;  中药疗法;  治疗; 临床研究性
Keywords:
osteoarthritis; knee;  acupuncture therapy;  drug therapy(TCD);  therapies; investigational
摘要:
目的:观察针刺配合口服骨力胶囊治疗膝关节骨性关节炎的临床疗效。方法:将60例膝关节骨性关节患者随机分为3组,每组20例,分别采用针刺、口服骨力胶囊、针刺配合口服骨力胶囊治疗。分别于治疗前和治疗1个疗程后,记录并比较3组患者膝关节功能评分,并于治疗1个疗程后比较3组患者的临床疗效。结果:①膝关节功能评分。治疗前3组患者膝关节功能评分比较,差异无统计学意义[(20.63±0.94)分,(20.60±1.99)分,(19.64±2.08)分,F=1.395,P=0.459)]。治疗1个疗程后3组患者膝关节功能评分比较,差异有统计学意义[(28.67±1.31)分,(32.08±0.98)分,(33.01±2.04)分,F=18.637,P=0.008)]。进一步两两比较,针刺配合口服骨力胶囊组膝关节功能评分高于针刺组和口服骨力胶囊组(P=0.002,P=0.001); 针刺组与口服骨力胶囊组比较,差异无统计学意义(P=0.157)。②临床疗效。针刺组临床控制2例、显效4例、有效10例、无效4例,口服骨力胶囊组显效3例、有效8例、无效9例,针刺配合口服骨力胶囊组临床控制3例、显效5例、有效12例。针刺配合口服骨力胶囊组的临床疗效优于其他2组(R^-针刺配合口服骨力胶囊组=22.82,R^-针刺组=29.65,R^-口服骨力胶囊组=39.02; χ2=0.129,P=0.006)。结论:采用针刺配合口服骨力胶囊治疗膝关节骨性关节炎,可以明显改善膝关节功能,疗效优于单纯采用针刺和口服骨力胶囊治疗,值得临床推广应用。
Abstract:
Objective:To observe the clinical curative effects of acupuncture therapy combined with oral application of Guli Jiaonang(骨力胶囊,GLJN)for treatment of knee osteoarthritis(KOA).Methods:Sixty patients with KOA were randomly divided into 3 groups,20 cases in each group.The patients were treated with acupuncture therapy(acupuncture group),oral application of GLJN(GLJN group)and acupuncture therapy combined with oral application of GLJN(Combination group)respectively.Knee function scores were recorded and compared between the 3 groups before treatment and after one course of treatment respectively,and the clinical curative effects were evaluated and compared between the 3 groups after one course of treatment.Results:There was no statistical difference in knee function scores between the 3 groups before treatment(20.63+/-0.94,20.60+/-1.99,19.64+/-2.08 points,F=1.395,P=0.459).There was statistical difference in knee function scores between the 3 groups after one course of treatment(28.67+/-1.31,32.08+/-0.98,33.01+/-2.04 points,F=18.637,P=0.008).Further pairwise comparison showed that the knee function score of combination group was higher than that of acupuncture group and GLJN group(P=0.002,P=0.001).There was no statistical difference between acupuncture group and GLJN group(P=0.157).The KOA of 2 patients were controlled,4 good,10 fair and 4 poor in acupuncture group; 3 patients got good result,8 fair and 9 poor in the GLJN group; while the KOA of 3 patients were controlled,5 good and 12 fair in combination group.The clinical curative effect was better in combination group compared with the other 2 groups(R^-combination group=22.82,R^-acupuncture group=29.65,R^-GLJN group=39.02; χ2=0.129,P=0.006).Conclusion:The therapy of acupuncture therapy combined with oral application of GLJN can obviously improve the function of knee in patients with KOA,and it surpasses the monotherapy of acupuncture therapy and oral application of GLJN in curative effect,so it is worthy of popularizing in clinic.

参考文献/References:

[1] 刘献祥.中医药治疗膝骨性关节炎的研究现状[J].中医正骨,2012,24(1),3-6.
[2] Hochberg MC,AItman RD,Brandt KD,et al.Guidelines for the medical management of osteoarthritis.PartⅡ.Osteoarthritis of the knee. American College of Rheumatology[J].Arthritis Rheum,1995,38(11):1541-1546.
[3] 董清平.推荐用“五十分加减法”评价膝关节功能[J].颈肩腰腿痛防治通讯,1986,7(1):27-28.
[4] 国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1996:186-201.
[5] 邓筱萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:349-353.
[6] 杨义靖,杨霞.小针刀治疗膝骨性关节炎30例[J].中医正骨,2011,23(7):48.
[7] 黄谨,苏培基,李大刚.中药薰洗治疗膝关节骨性关节炎的系统评价[J].中医正骨,2013,25(7):31-35.
[8] 冯欢欢,王培民,范竞,等.膝骨关节炎X线表现与膝关节疼痛程度的相关性分析[J].中医正骨,2013,25(6),29-30.
[9] 唐萌芽,翁祝承,邵利芳.中药治疗膝骨关节炎临床疗效和安全性的系统评价[J].中医正骨,2014,26(1):43-47.
[10] 苏泉,鲁光钱.针刺配合关节腔注射和中药内服治疗膝骨关节炎53例[J].中医正骨,2014,26(5):35-36.

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备注/Memo

备注/Memo:
2014-09-01收稿 2014-11-13修回
通讯作者:任树军 E-mail:15244603358@163.com
更新日期/Last Update: 2015-01-30