参考文献/References:
[1] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南(2022)[J].中国全科医学,2023,26(14):1671-1691.
[2] 林贤灿,陈桐莹,林燕平,等.原发性骨质疏松症的中医认识与探索[J].中国骨质疏松杂志,2023,29(6):870-874.
[3] 《老年性骨质疏松症中西医结合诊疗指南》工作组,史晓林,刘康.老年性骨质疏松症中西医结合诊疗指南[J].中国骨质疏松杂志,2024,30(7):937-946.
[4] HWANG E S,YOON G,KANG H T.A comparative analysis of the cell biology of senescence and aging[J].Cell Mol Life Sci,2009,66(15):2503-2524.
[5] HARMAN D.Aging:a theory based on free radical and radiation chemistry[J].J Gerontol,1956,11(3):298-300.
[6] WILEY C D,VELARDE M C,LECOT P,et al.Mitochondrial dysfunction induces senescence with a distinct secretory phenotype[J].Cell Metab,2016,23(2):303-314.
[7] 陈明杏,文皓楠,刘小钰,等.线粒体自噬在绝经后骨质疏松症中的调控机制[J].辽宁中医药大学学报,2025,27(4):209-214.
[8] 汪荣贵.六味地黄汤加味治疗老年骨质疏松的疗效评估[J].临床医药文献电子杂志,2020,7(32):129.
[9] 孙福波.探讨左归丸联合鲑鱼降钙素治疗老年骨质疏松症的效果[J].中西医结合心血管病电子杂志,2019,7(16):167.
[10] 马清华,张竞.补中益气汤加减对老年性骨质疏松(脾肾两虚证)的临床疗效分析[J].中医药临床杂志,2017,29(4):551-553.
[11] 李颖,黄宏兴,吴伙燕,等.线粒体DNA相关因子与骨质疏松症中医证型的关系研究[J].广州中医药大学学报,2015,32(4):656-660.
[12] 何剑全.护骨素、核因子kB受体活化因子配体与老年骨质疏松症中医证型关系初探[D].福州:福建中医药大学,2012.
[13] 李燕南,田瀚,刘树华,等.血清POT1、TERT、8-OHdG、SOD表达水平与骨质疏松症证型的相关性分析[J].现代医院,2024,24(3):486-489.
[14] 黄佳纯,黄宏兴,万雷,等.脾肾-肌骨-线粒体理论探析[J].中国骨质疏松杂志,2021,27(12):1844-1847.
[15] ZHU Z,WANG X.Significance of mitochondria DNA mutations in diseases[J].Adv Exp Med Biol,2017,1038:219-230.
[16] ZHU Y,YOU J,XU C,et al.Associations of mitochondrial DNA 3777—4679 region mutations with maternally inherited essential hypertensive subjects in China[J].BMC Med Genet,2020,21(1):105.
[17] GAO X,YU X,ZHANG C,et al.Telomeres and mitochondrial metabolism:implications for cellular senescence and age-related diseases[J].Stem Cell Rev Rep,2022,18(7):2315-2327.
[18] GUANTES R,RASTROJO A,NEVES R,et al.Global variability in gene expression and alternative splicing is modulated by mitochondrial content[J].Genome Res,2015,25(5):633-644.
[19] TRIFUNOVIC A,WREDENBERG A,FALKENBERG M,et al.Premature ageing in mice expressing defective mitochondrial DNA polymerase[J].Nature,2004,429(6990):417-423.
[20] LANE R K,HILSABECK T,REA S L.The role of mitochondrial dysfunction in age-related diseases[J].Biochim Biophys Acta,2015,1847(11):1387-1400.
[21] DOBSON P F,DENNIS E P,HIPPS D,et al.Mitochondrial dysfunction impairs osteogenesis,increases osteoclast activity,and accelerates age related bone loss[J].Sci Rep,2020,10(1):11643.
[22] PIGNOLO R J,CHANDRA A.Insights into age-related osteoporosis from senescence-based preclinical models and human accelerated aging paradigms[J].Mech Ageing Dev,2025,224:112025.
[23] LIU J,GAO Z,LIU X.Mitochondrial dysfunction and therapeutic perspectives in osteoporosis[J].Front Endocrinol(Lausanne),2024,15:1325317.
[24] WANG N,HAO Y,FU L.Trimethylamine-N-oxide promotes osteoclast differentiation and bone loss via activating ROS-dependent NF-κB signaling pathway[J].Nutrients,2022,14(19):3955.
[25] CHEN K,QIU P,YUAN Y,et al.Pseurotin a inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppressing reactive oxygen species[J].Theranostics,2019,9(6):1634-1650.
[26] ZHANG C,LI H,LI J,et al.Oxidative stress:a common pathological state in a high-risk population for osteoporosis[J].Biomed Pharmacother,2023,163:114834.
[27] XIAO L,ZHONG M,HUANG Y,et al.Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways[J].Aging(Albany NY),2020,12(21):21706-21729.
[28] FENG X,LIU Z,SU Y,et al.Tussilagone inhibits osteoclastogenesis by modulating mitochondrial function and ROS production involved Nrf-2 activation[J].Biochem Pharmacol,2023,218:115895.
[29] VIVES-BAUZA C,ZHOU C,HUANG Y,et al.PINK1-dependent recruitment of Parkin to mitochondria in mitophagy[J].Science,2010,107(1):378-383.
[30] WANG S,DENG Z,MA Y,et al.The role of autophagy and mitophagy in bone metabolic disorders[J].Int J Biol Sci,2020,16(14):2675-2691.
[31] QADIR A,LIANG S,WU Z,et al.Senile osteoporosis:the involvement of differentiation and senescence of bone marrow stromal cells[J].Int J Mol Sci,2020,21(1):349.
[32] GUO Y,JIA X,CUI Y,et al.Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis[J].Redox Biology,2021,41:101915.
[33] HU S,WANG S.The role of SIRT3 in the osteoporosis[J].Front Endocrinol(Lausanne),2022,13:893678.
[34] LIU F,YUAN L,LI L,et al.S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis[J].Pharmacol Res,2023,192:106788.
[35] OLIVER L,HUE E,PRIAULT M,et al.Basal autophagy decreased during the differentiation of human adult mesenchymal stem cells[J].Stem Cells Dev,2012,21(15):2779-2788.
[36] GARCÍA-PRAT L,MARTÍNEZ-VICENTE M,PERDIGUERO E,et al.Autophagy maintains stemness by preventing senescence[J].Nature,2016,529(7584):37-42.
[37] WAN Y,ZHUO N,LI Y,et al.Autophagy promotes osteogenic differentiation of human bone marrow mesenchymal stem cell derived from osteoporotic vertebrae[J].Biochem Biophys Res Commun,2017,488(1):46-52.
[38] ONISHI M,YAMANO K,SATO M,et al.Molecular mechanisms and physiological functions of mitophagy[J].EMBO J,2021,40(3):e104705.
[39] GUILBAUD E,SAROSIEK K A,GALLUZZI L.Inflammation and mitophagy are mitochondrial checkpoints to aging[J].Nat Commun,2024,15(1):3375.
[40] 中国老年学和老年医学学会骨质疏松分会肌肉、骨骼与骨质疏松学科组.肌肉、骨骼与骨质疏松专家共识[J].中国骨质疏松杂志,2016,22(10):1221-1229.
[41] LUO J,SHEN S,XIA J,et al.Mitochondria as the essence of yang qi in the human body[J].Phenomics,2022,2(5):336-348.
[42] 付夜平,钟妍苑,杨芳,等.补肾健脾法在BMSCs成骨分化中ULK1/FUNDC1介导线粒体自噬研究[J].中国骨质疏松杂志,2025,31(2):157-162.
[43] 龚博炀.基于骨髓间充质干细胞探讨八子补肾胶囊通过线粒体自噬抗老年性骨质疏松的作用及机制研究[D].天津:天津中医药大学,2024.
[44] 李颖,吴伙燕,黄宏兴,等.补肾健脾中药复方对去势大鼠骨骼肌线粒体通透转孔调控的研究[J].中国骨质疏松杂志,2012,18(12):1131-1134.
[45] LEONG P K,CHEN N,KO K M.Mitochondrial decay in ageing:‘Qi-invigorating'schisandrin B as a hormetic agent for mitigating age-related diseases[J].Clin Exp Pharmacol Physiol,2012,39(3):256-264.
[46] KWAN K,DONG T,TSIM K.Danggui Buxue Tang,a Chinese herbal decoction containing Astragali Radix and Angelicae Sinensis Radix,improves mitochrondial bioenergetics in osteoblast[J].Phytomedicine,2021,88:153605.
[47] 马宏侠,王小红,唐秀丽,等.补中益气汤加味治疗老年性骨质疏松症45例临床研究[J].河北中医,2014,36(5):696-697.
[48] 吴亚东,郭振光,邓文杰,等.基于“脾主肌肉”探讨补中益气汤对骨质疏松椎体压缩性骨折术后临床疗效及骨转换标志物的影响[J].中国实验方剂学杂志,2022,28(17):91-97.
[49] HUA Z,DAI S,LI S,et al.Deciphering the protective effect of Buzhong Yiqi Decoction on osteoporotic fracture through network pharmacology and experimental validation[J].J Orthop Surg Res,2023,18(1):86.
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