[1]雷腾飞,张玉民,熊轶喆,等.复方紫荆消伤巴布膏外用联合益气活血方内服治疗神经根型颈椎病的临床研究[J].中医正骨,2018,30(03):13-16，21.
　LEI Tengfei,ZHANG Yumin,XIONG Yizhe,et al.A clinical study of external application of Fufang Zijing Xiaoshang Babugao(复方紫荆消伤巴布膏)combined with oral application of Yiqi Huoxue Fang(益气活血方)for treatment of cervical spondylotic radiculopathy[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2018,30(03):13-16，21.
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复方紫荆消伤巴布膏外用联合益气活血方内服治疗神经根型颈椎病的临床研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期数:
2018年03期
页码:
13-16，21
栏目:
颈椎疾患
出版日期:
2018-03-20

文章信息/Info

Title:
A clinical study of external application of Fufang Zijing Xiaoshang Babugao(复方紫荆消伤巴布膏)combined with oral application of Yiqi Huoxue Fang(益气活血方)for treatment of cervical spondylotic radiculopathy
作者:
雷腾飞1; 张玉民1; 熊轶喆1; 陈博1; 胡零三1; 黄海生2; 詹红生1
1.上海中医药大学附属曙光医院,上海市中医药研究院骨伤科研究所,上海 201203; 2.上海市中西医结合医院,上海 200082
Author(s):
LEI Tengfei1; ZHANG Yumin1; XIONG Yizhe1; CHEN Bo1; HU Lingsan1; HUANG Haisheng2; ZHAN Hongsheng1
1.Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China 2.Shanghai combinational hospital of traditional Chinese medicine and Western medicine,Shanghai 200082,China
关键词:
颈椎病;  神经根病;  益气活血方;  复方紫荆消伤巴布膏;  临床试验
Keywords:
Keywords cervical spondylosis;  radiculopathy;  Yiqi Huoxue Fang;  Fufang Zijing Xiaoshang Babugao;  clinical trial
摘要:
目的:观察复方紫荆消伤巴布膏外用联合益气活血方内服治疗神经根型颈椎病的临床疗效。方法:将90例神经根型颈椎病患者随机分为3组,其中采用复方紫荆消伤巴布膏外用37例(复方紫荆消伤巴布膏组)、采用益气活血方内服29例(益气活血方组)、采用复方紫荆消伤巴布膏外用联合益气活血方内服24例(复方紫荆消伤巴布膏联合益气活血方组)。复方紫荆消伤巴布膏外贴每天1次,每次12 h,连用6周; 益气活血方内服每日1剂,早晚2次服用,连服6周。分别于治疗前及治疗开始后2周、4周、6周记录并比较3组患者颈部疼痛视觉模拟量表(visual analogue scale,VAS)评分和颈椎功能障碍指数(neck disability index,NDI)。结果:①颈部疼痛VAS评分。时间因素和分组因素不存在交互效应(F=2.250,P=0.058); 3组患者颈部疼痛VAS评分比较,组间差异无统计学意义,不存在分组效应(F=1.528,P=0.218); 治疗前后不同时间点之间颈部疼痛VAS评分的差异有统计学意义,存在时间效应(F=57.080,P=0.000); 3组颈部疼痛VAS评分随时间均呈降低趋势,且3组的降低趋势完全一致[(4.84±1.68)分,(3.62±1.69)分,(2.54±1.88)分,(1.74±1.24)分,F=85.491,P=0.000;(5.14±1.98)分,(4.17±2.19)分,(2.59±1.80)分,(1.84±1.52)分,F=42.705,P=0.000;(5.42±1.67)分,(3.46±1.96)分,(1.83±1.61)分,(1.06±0.63)分,F=42.863,P=0.000]。②NDI。时间因素和分组因素存在交互效应(F=1.930,P=0.026); 3组患者NDI比较,组间差异有统计学意义,存在分组效应(F=3.782,P=0.017); 治疗前后不同时间点之间NDI的差异有统计学意义,存在时间效应(F=40.546,P=0.000); 3组NDI随时间均呈降低趋势,但3组的降低趋势不完全一致; 治疗前和治疗开始后2周,3组NDI比较,组间差异均无统计学意义[(22.54±8.39)%,(20.70±7.48)%,(24.65±8.45)%,F=1.632,P=0.195;(17.50±6.54)%,(17.60±6.41)%,(13.10±4.23)%,F=1.863,P=0.210]; 治疗开始后4周和6周,3组NDI比较,组间差异均有统计学意义[(11.31±3.19)%,(13.56±4.45)%,(7.33±2.56)%,F=2.754,P=0.028;(7.82±4.32)%,(9.58±3.26)%,(4.73±2.10)%,F=7.458,P=0.013]; 复方紫荆消伤巴布膏组、益气活血方组NDI均高于复方紫荆消伤巴布膏联合益气活血方组(P=0.008,P=0.039; P=0.011,P=0.006),复方紫荆消伤巴布膏组NDI与益气活血方组比较差异均无统计学意义(P=0.148,P=0.174)。结论:复方紫荆消伤巴布膏外用联合益气活血方内服治疗神经根型颈椎病,能够缓解颈部疼痛,改善颈椎功能,且在改善颈椎功能方面优于单纯复方紫荆消伤巴布膏外用和单纯益气活血方内服,值得临床推广应用。
Abstract:
ABSTRACT Objective:To observe the clinical curative effects of external application of Fufang Zijing Xiaoshang Babugao(复方紫荆消伤巴布膏,FFZJXSBBG)combined with oral application of Yiqi Huoxue Fang(益气活血方,YQHXF)for treatment of cervical spondylotic radiculopathy(CSR).Methods:Ninety patients with CSR were randomly divided into 3 groups,37 patients were treated with external application of FFZJXSBBG(FFZJXSBBG group),29 patients were treatd with oral application of YQHXF(YQHXF group),while the others were treated with external application of FFZJXSBBG combined with oral application of YQHXF(combination treatment group).FFZJXSBBG were applied once a day,12 hours at a time for consecutive 6 weeks; while YQHXF were taken one dose a day in the morning and evening respectively for consecutive 6 weeks.Neck pain visual analogue scale(VAS)scores and neck disability index(NDI)were recorded and compared between the 3 groups before treatment and at 2,4 and 6 weeks after the beginning of the treatment respectively.Results:The analytic results of neck pain VAS scores showed that(1)there was no interaction between time factor and group factor(F=2.250,P=0.058);(2)there was no statistical difference in neck pain VAS scores between the 3 groups,in other words,there was no group effect(F=1.528,P=0.218);(3)there was statistical difference in the neck pain VAS scores between different timepoints before and after the treatment,in other words,there was time effect(F=57.080,P=0.000); and(4)the neck pain VAS scores presented a time-dependent decreasing trend in the 3 groups and the 3 groups were consistent with each other in the decreasing trend of neck pain VAS scores(4.84+/-1.68,3.62+/-1.69,2.54+/-1.88,1.74+/-1.24 points,F=85.491,P=0.000; 5.14+/-1.98,4.17+/-2.19,2.59+/-1.80,1.84+/-1.52 points,F=42.705,P=0.000; 5.42+/-1.67,3.46+/-1.96,1.83+/-1.61,1.06+/-0.63 points,F=42.863,P=0.000).The analytic results of NDI showed that(1)there was interaction between time factor and group factor(F=1.930,P=0.026);(2)there was statistical difference in NDI between the 3 groups,in other words,there was group effect(F=3.782,P=0.017);(3)there was statistical difference in NDI between different timepoints before and after the treatment,in other words,there was time effect(F=40.546,P=0.000);(4)the NDI presented a time-dependent decreasing trend in the 3 groups while the 3 groups were inconsistent with each other in the decreasing trend of NDI;(5)there was no statistical difference in NDI between the 3 groups before treatment and at 2 weeks after the beginning of the treatment(22.54+/-8.39,20.70+/-7.48,24.65+/-8.45%,F=1.632,P=0.195; 17.50+/-6.54,17.60+/-6.41,13.10+/-4.23%,F=1.863,P=0.210);(6)there was statistical difference in NDI between the 3 groups at 4 and 6 weeks after the beginning of the treatment(11.31+/-3.19,13.56+/-4.45,7.33+/-2.56%,F=2.754,P=0.028; 7.82+/-4.32,9.58+/-3.26,4.73+/-2.10%,F=7.458,P=0.013); and(7)the NDI were higher in FFZJXSBBG group and YQHXF group compared to combination treatment group(P=0.008,P=0.039; P=0.011,P=0.006)and there was no statistical difference in NDI between FFZJXSBBG group and YQHXF group(P=0.148,P=0.174).Conclusion:Combination of external application of FFZJXSBBG with oral application of YQHXF can relieve neck pain and improve cervical vertebra function in treatment of CSR,and it is superior to the monotherapy of external application of FFZJXSBBG and the monotherapy of oral application of YQHXF in improving cervical vertebra function,so it is worthy of popularizing in clinic.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(81473702); 国家自然科学基金青年科学基金项目(81503596); 上海市科学技术委员会科研计划项目(14401970402,15401934100); 上海市进一步加快中医药事业发展三年行动计划建设(2014—2016年)项目(ZY3-LCPT-2-1005); 上海市市级医院新兴前沿技术联合攻关项目(SHDC12014121) 通讯作者:詹红生 E-mail:zhanhongsheng2010@163.com
更新日期/Last Update: 2018-08-02