[1]伏玉龙,郭珈宜,李峰,等.间充质干细胞来源外泌体修复膝骨关节炎软骨损伤作用机制的研究进展[J].中医正骨,2023,35(11):76-79.
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间充质干细胞来源外泌体修复膝骨关节炎软骨损伤作用机制的研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期数:
2023年11期
页码:
76-79
栏目:
综述
出版日期:
2023-11-20

文章信息/Info

作者:
伏玉龙1郭珈宜2李峰2张亦可1曹坤燕1
1.河南中医药大学研究生院,河南 郑州 450046; 2.河南省洛阳正骨医院/河南省骨科医院,河南 洛阳 471002
关键词:
骨关节炎 软骨关节 间质干细胞 外泌体 综述
摘要:
膝骨关节炎(knee osteoarthritis,KOA)是临床上常见的退行性骨关节疾病,目前临床上尚缺乏能够有效遏制其进展的治疗方法。间充质干细胞来源外泌体(mesenchymal stem cell-derived exosome,MSC-EXO)在KOA软骨损伤修复中具有显著的优势,关节腔注射MSC-EXO有望成为治疗KOA的重要疗法。本文对MSC-EXO进行了概述,并从抑制软骨细胞外基质降解、调控软骨细胞增殖与凋亡、抑制炎症反应和增强软骨细胞自噬等方面,对MSC-EXO修复KOA软骨损伤作用机制的研究进展进行了综述。

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备注/Memo

备注/Memo:
基金项目:河南省中医药传承与创新人才工程(仲景工程)中医药拔尖人才项目(豫卫中医函〔2021〕15号); 全国中医学术流派传承工作室建设项目(国中医药人教函〔2019〕62号); 河南省中医药科学研究专项课题(20-21ZY1005,2022ZYZD17)
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更新日期/Last Update: 1900-01-01