[1]田增辉,陈云刚,李颖颖,等.干细胞外泌体治疗椎间盘退变作用机制的研究进展[J].中医正骨,2022,34(12):56-59.
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干细胞外泌体治疗椎间盘退变作用机制的研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第34卷
期数:
2022年12期
页码:
56-59
栏目:
综述
出版日期:
2022-12-02

文章信息/Info

作者:
田增辉1陈云刚2李颖颖1郭金星1郑健虎1郝延科2
(1.山东中医药大学第一临床医学院,山东 济南 250014; 2.山东中医药大学附属医院,山东 济南 250014)
关键词:
椎间盘退化 干细胞 外泌体 综述
摘要:
椎间盘退变是引起颈部、腰部疼痛的重要原因之一。目前,临床上治疗椎间盘退变引起疼痛的方法均不能干预椎间盘退变的进程或逆转椎间盘退变。随着对干细胞研究的不断深入,干细胞外泌体治疗椎间盘退变逐渐成为新的研究方向。本文对椎间盘退变的机制及干细胞外泌体的特性进行了概述,并从干细胞外泌体抑制细胞凋亡、抑制炎症因子表达、维持细胞外基质代谢平衡等方面对干细胞外泌体治疗椎间盘退变作用机制的研究进展进行了综述。

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(收稿日期:2022-06-06 本文编辑:吕宁)

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备注/Memo

备注/Memo:
基金项目:山东省自然科学基金面上项目(ZR2022MH096,ZR2021MH254); 山东省重点研发计划项目(2018GSF119011); 济南市科技计划项目(201805082) 通讯作者:郝延科 E-mail:haoyanke@126.com
更新日期/Last Update: 1900-01-01