参考文献/References:
[1] MÄÄTTÄ J H,WADGE S,MACGREGOR A,et al.ISSLS Prize Winner:vertebral endplate(Modic)change is an independent risk factor for episodes of severe and disabling low back pain[J].Spine(Phila Pa 1976),2015,40(15):1187-1193.
[2] MUNIR S,FREIDIN M B,RADE M,et al.Endplate defect is heritable,associated with low back pain and triggers intervertebral disc degeneration:a longitudinal study from twins UK[J].Spine(Phila Pa 1976),2018,43(21):1496-1501.
[3] SAUKKONEN J,MÄÄTTÄ J,OURA P,et al.Association between Modic changes and low back pain in middle age:A Northern Finland birth cohort study[J].Spine(Phila Pa 1976),2020,45(19):1360-1367.
[4] GBD 2017 Disease and Injury Incidence and Prevalence Collaborators.Global,regional,and national incidence,prevalence,and years lived with disability for 354 diseases and injuries for 195 countries and territories,1990-2017:a systematic analysis for the Global Burden of Disease Study 2017[J].Lancet,2018,392(10159):1789-1858.
[5] CROCKETT M T,KELLY B S,VAN BAARSEL S,et al.Modic type 1 vertebral endplate changes:injury,inflammation,or infection?[J].AJR Am J Roentgenol,2017,209(1):167-170.
[6] HAN C,KUANG M J,MA J X,et al.Prevalence of Modic changes in the lumbar vertebrae and their associations with workload,smoking and weight in northern China[J/OL].Sci Rep,2017,7:46341[2022-04-06].https://pubmed.ncbi.nlm.nih.gov/28402320/.
[7] ÖZCAN-EK
�瘙塁
I E E,TURGUT V U,KÜÇÜKSÜLEYMANO GLU D,et al.Obesity could be associated with poor paraspinal muscle quality at upper lumbar levels and degenerated spine at lower lumbar levels:Is this a domino effect[J].J Clin Neurosci,2021,94:120-127.
[8] KUISMA M,KARPPINEN J,NIINIMÄKI J,et al.Modic changes in endplates of lumbar vertebral bodies:prevalence and association with low back and sciatic pain among middle-aged male workers[J].Spine(Phila Pa 1976),2007,32(10):1116-1122.
[9] URBAN J P,SMITH S,FAIRBANK J.Nutrition of the intervertebral disc[J].Spine(Phila Pa 1976),2005,29(23):2700-2709.
[10] MOON H J,KIM J H,LEE H S,et al.Annulus fibrosus cells interact with neuron-like cells to modulate production of growth factors and cytokines in symptomatic disc degeneration[J].Spine(Phila Pa 1976),2012,37(1):2-9.
[11] ZELOVÁ H,HOSEK J.TNF-α signalling and inflammation:interactions between old acquaintances[J].Inflamm Res,2013,62(7):641-651.
[12] RAJASEKARAN S,SOUNDARARAJAN D C R,NAYAGAM S M,et al.Modic changes are associated with activation of intense inflammatory and host defense response pathways-molecular insights from proteomic analysis of human intervertebral discs[J].Spine J,2022,22(1):19-38.
[13] WALTER B A,PURMESSUR D,LIKHITPANICHKUL M,et al.Inflammatory kinetics and efficacy of anti-inflammatory treatments on human nucleus pulposus cells[J].Spine(Phila Pa 1976),2015,40(13):955-963.
[14] STIRLING A,WORTHINGTON T,RAFIQ M,et al.Association between sciatica and Propionibacterium acnes[J].Lancet,2001,357(9273):2024-2025.
[15] YUAN Y,ZHOU Z,JIAO Y,et al.Histological identification of propionibacterium acnes in nonpyogenic degenerated intervertebral discs[J/OL].Biomed Res Int,2017,2017:6192935[2022-04-06].https://pubmed.ncbi.nlm.nih.gov/28401158/.
[16] SALEHPOUR F,AGHAZADEH J,MIRZAEI F,et al.Propionibacterium acnes infection in disc material and different antibiotic susceptibility in patients with lumbar disc herniation[J].Int J Spine Surg,2019,13(2):146-152.
[17] AGHAZADEH J,SALEHPOUR F,ZIAEII E,et al.Modic changes in the adjacent vertebrae due to disc material infection with Propionibacterium acnes in patients with lumbar disc herniation[J].Eur Spine J,2017,26(12):3129-3134.
[18] AHMED-YAHIA S,DECOUSSER J W,FLOUZAT-LACHANIETTE C H,et al.Is the discopathy associated with Modic changes an infectious process?Results from a prospective monocenter study[J/OL].PLoS One,2019,14(8):e0221030[2022-04-06].https://pubmed.ncbi.nlm.nih.gov/31415619/.
[19] RIGAL J,THELEN T,BYRNE F,et al.Prospective study using anterior approach did not show association between Modic 1 changes and low grade infection in lumbar spine[J].Eur Spine J,2016,25(4):1000-1005.
[20] THURSTON T L,WANDEL M P,VON MUHLINEN N,et al.Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion[J].Nature,2012,482(7385):414-418.
[21] XU T,GUO Y,QI X.Ubiquitination-mediated inflammasome activation during bacterial infection[J].Int J Mol Sci,2019,20(9):2110.
[22] RAJASEKARAN S,CHITRAA T,DILIP CHAND RAJA S,et al.Subclinical infection can be an initiator of inflammaging leading to degenerative disk disease:evidence from host-defense response mechanisms[J].Eur Spine J,2021,30(9):2586-2604.
[23] DJURIC N,RAJASEKARAN S,TANGAVEL C,et al.Influence of endplate avulsion and Modic changes on the inflammation profile of herniated discs:a proteomic and bioinformatic approach[J].Eur Spine J,2022,31(2):389-399.
[24] KARPPINEN J,DAAVITTILA I,SOLOVIEVA S,et al.Genetic factors are associated with modic changes in endplates of lumbar vertebral bodies[J].Spine(Phila Pa 1976),2008,33(11):1236-1241.
[25] KANNA R M,SHANMUGANATHAN R,RAJAGOPALAN V R,et al.Prevalence,patterns,and genetic association analysis of Modic vertebral endplate changes[J].Asian Spine J,2017,11(4):594-600.
[26] MÄÄTTÄ J H,KRAATARI M,WOLBER L,et al.Vertebral endplate change as a feature of intervertebral disc degeneration:a heritability study[J].Eur Spine J,2014,23(9):1856-1862.
[27] XIAO L,NI C,SHI J,et al.Analysis of correlation between vertebral endplate change and lumbar disc degeneration[J].Med Sci Monit,2017,23:4932-4938.
[28] HAYASHI T,DAUBS M D,SUZUKI A,et al.Motion characteristics and related factors of Modic changes in the lumbar spine[J].J Neurosurg Spine,2015,22(5):511-517.
[29] WU H L,DING W Y,SHEN Y,et al.Prevalence of vertebral endplate modic changes in degenerative lumbar scoliosis and its associated factors analysis[J].Spine(Phila Pa 1976),2012,37(23):1958-1964.
[30] YAMAN M E,KAZANCI A,YAMAN N D,et al.Factors that influence recurrent lumbar disc herniation[J].Hong Kong Med J,2017,23(3):258-263.
[31] KAWAGUCHI K,HARIMAYA K,MATSUMOTO Y,et al.Effect of cartilaginous endplates on extruded disc resorption in lumbar disc herniation[J/OL].PLoS One,2018,13(4):e0195946[2022-04-06].https://pubmed.ncbi.nlm.nih.gov/29664923/.
[32] HAO L,LI S,LIU J,et al.Recurrent disc herniation following percutaneous endoscopic lumbar discectomy preferentially occurs when Modic changes are present[J].J Orthop Surg Res,2020,15(1):176.
[33] KUMARASAMY D,RAJASEKARAN S,ANAND K S S V,et al.Lumbar disc herniation and preoperative Modic changes:a prospective analysis of the clinical outcomes after microdiscectomy[J].Global Spine J,2022,12(5):940-951.
[34] PRADIP I A,DILIP CHAND RAJA S,RAJASEKARAN S,et al.Presence of preoperative Modic changes and severity of endplate damage score are independent risk factors for developing postoperative surgical site infection:a retrospective case-control study of 1124 patients[J].Eur Spine J,2021,30(6):1732-1743.
[35] 王牧一,徐亮,邱勇,等. Modic改变对腰椎经椎间孔椎间融合效果和融合器沉降的影响[J].中华医学杂志,2019,99(47):3703-3709.
[36] TAKAHASHI H,AOKI Y,INOUE M,et al.Characteristics of relief and residual low back pain after discectomy in patients with lumbar disc herniation:analysis using a detailed visual analog scale[J].BMC Musculoskelet Disord,2021,22(1):167.
[37] XU J,LI Y,WANG B,et al.Percutaneous endoscopic lumbar discectomy for lumbar disc herniation with Modic changes via a transforaminal approach:a retrospective study[J].Pain Physician,2019,22(6):E601-E608.
[38] MERA Y,TERAGUCHI M,HASHIZUME H,et al.Association between types of Modic changes in the lumbar region and low back pain in a large cohort: the Wakayama spine study[J].Eur Spine J,2021,30(4):1011-1017.
[39] TERAGUCHI M,HASHIZUME H,OKA H,et al.Detailed subphenotyping of lumbar Modic changes and their association with low back pain in a large population-based study:the wakayama spine study[J].Pain Ther,2022,11(1):57-71.
[40] CHEN Y,BAO J,YAN Q,et al.Distribution of Modic changes in patients with low back pain and its related factors[J].Eur J Med Res,2019,24(1):34.
[41] HANIMOGLU H,ÇEVIK S,YILMAZ H,et al.Effects of Modic type 1 changes in the vertebrae on low back pain[J].World Neurosurg,2019,121:e426-e432.
[42] JENSEN T S,KARPPINEN J,SORENSEN J S,et al.Vertebral endplate signal changes(Modic change):a systematic literature review of prevalence and association with non-specific low back pain[J].Eur Spine J,2008,17(11):1407-1422.
[43] TIAN Q H,LU Y Y,SUN X Q,et al.Feasibility of percutaneous lumbar discectomy combined with percutaneous cementoplasty for symptomatic lumbar disc herniation with modic type I endplate changes[J].Pain Physician,2017,20(4):E481-E488.
[44] GJEFSEN E,BRÅTEN L C H,GOLL G L,et al.The effect of infliximab in patients with chronic low back pain and Modic changes(the BackToBasic study):study protocol of a randomized,double blind,placebo-controlled,multicenter trial[J].BMC Musculoskelet Disord,2020,21(1):698.
[45] SIEPER J,PODDUBNYY D.Axial spondyloarthritis[J].Lancet,2017,390(10089):73-84.
[46] VAN DER HEIJDE D,RAMIRO S,LANDEWÉ R,et al.2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis[J].Ann Rheum Dis,2017,76(6):978-991.
[47] SÁNCHEZ-ROBLES E M,GIRN R,PANIAGUA N,et al.Monoclonal antibodies for chronic pain treatment:present and future[J].Int J Mol Sci,2021,22(19):10325.
[48] ALBERT H B,SORENSEN J S,CHRISTENSEN B S,et al.Antibiotic treatment in patients with chronic low back pain and vertebral bone edema(Modic type 1 changes):a double-blind randomized clinical controlled trial of efficacy[J].Eur Spine J,2013,22(4):697-707.
[49] MANNICHE C,HALL G M.Chronic low back pain,Modic changes and low-grade virulent infection:efficacy of antibiotic treatment[J].Future Sci OA,2021,7(6):FSO703.
[50] CAO P,JIANG L,ZHUANG C,et al.Intradiscal injection therapy for degenerative chronic discogenic low back pain with end plate Modic changes[J].Spine J,2011,11(2):100-106.
[51] MEFFORD J,SAIRYO K,SAKAI T,et al.Modic type I changes of the lumbar spine in golfers[J].Skeletal Radiol,2011,40(4):467-473.
[52] CAI G,LASLETT L L,AITKEN D,et al.Effect of zoledronic acid and denosumab in patients with low back pain and Modic change:a proof-of-principle trial[J].J Bone Miner Res,2018,33(5):773-782.
[53] 袁仕国,张志伟,徐明奎,等.Modic改变分型的慢性非特异性腰痛的推拿近期疗效[J].世界科学技术-中医药现代化,2014,16(10):2102-2105.
[54] CRANE J D,OGBORN D I,CUPIDO C,et al.Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage[J/OL].Sci Transl Med,2012,4(119):119ra13[2022-04-06].https://pubmed.ncbi.nlm.nih.gov/22301554/.
[55] 顾非,黄盠,王峻良,等.三步推拿法改善腰椎间盘突出症患者腰椎曲度的研究[J].中国医药导报,2013,10(19):115-117.
[56] BAHR T,ALLRED K,MARTINEZ D,et al.Effects of a massage-like essential oil application procedure using copaiba and deep blue oils in individuals with hand arthritis[J].Complement Ther Clin Pract,2018,33:170-176.
[57] ZHANG R,LAO L,REN K,et al.Mechanisms of acupuncture-electroacupuncture on persistent pain[J].Anesthesiology,2014,120(2):482-503.
[58] LI Y,YANG M,WU F,et al.Mechanism of electroacupuncture on inflammatory pain:neural-immune-endocrine interactions[J].J Tradit Chin Med,2019,39(5):740-749.
[59] SUN J,ZHANG H,WANG C,et al.Regulating the balance of Th17/Treg via electroacupuncture and moxibustion:an ulcerative colitis mice model based study[J/OL].Evid Based Complement Alternat Med,2017,2017:7296353[2022-04-06].https://pubmed.ncbi.nlm.nih.gov/29391874/.
[60] DA SILVA M D,BOBINSKI F,SATO K L,et al.IL-10 cytokine released from M2 macrophages is crucial for analgesic and anti-inflammatory effects of acupuncture in a model of inflammatory muscle pain[J].Mol Neurobiol,2015,51(1):19-31.
[61] SAIRYO K,MAEDA T,YAMASHITA K,et al.A new surgical strategy for the intractable chronic low back pain due to type 1 Modic change using transforaminal full-endoscopic disc cleaning(FEDC)surgery under the local anesthesia:A case report and literature review[J].J Med Invest,2021,68(1.2):1-5.
[62] CONGER A,SCHUSTER N M,CHENG D S,et al.The effectiveness of intraosseous basivertebral nerve radiofrequency neurotomy for the treatment of chronic low back pain in patients with Modic changes:a systematic review[J].Pain Med,2021,22(5):1039-1054.
[63] MICHALIK A,CONGER A,SMUCK M,et al.Intraosseous basivertebral nerve radiofrequency ablation for the treatment of vertebral body endplate low back pain:current evidence and future directions[J].Pain Med,2021,22(Suppl 1):S24-S30.
(收稿日期:2022-04-07 本文编辑:郭毅曼)