[1]林涛,郭艳幸,吴丽芳,等.三伏贴贴敷联合臭氧关节腔注射治疗膝骨关节炎阳虚寒凝证[J].中医正骨,2021,33(07):59-61.
　LIN Tao,GUO Yanxing,WU Lifang,et al.External application of dog-days strapping combined with knee intra-articular injection of medical ozone for treatment of knee osteoarthritis with yang-deficiency and cold-congelation syndrome[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2021,33(07):59-61.
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三伏贴贴敷联合臭氧关节腔注射治疗膝骨关节炎阳虚寒凝证()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第33卷
期数:
2021年07期
页码:
59-61
栏目:
临床报道
出版日期:
2021-07-20

文章信息/Info

Title:
External application of dog-days strapping combined with knee intra-articular injection of medical ozone for treatment of knee osteoarthritis with yang-deficiency and cold-congelation syndrome
作者:
林涛1; 郭艳幸2; 吴丽芳1; 郑梓灌1; 张慧铭1; 陈燕超1
(1.厦门医学院附属第二医院,福建 厦门 361021; 2.河南省洛阳正骨医院/河南省骨科医院,河南 洛阳 471002)
Author(s):
LIN Tao; GUO Yanxing; WU Lifang; ZHENG Ziguan; ZHANG Huiming; CHEN Yanchao
关键词:
骨关节炎; 膝;  阳虚寒凝证;  三伏贴;  臭氧
摘要:
目的:探讨三伏贴贴敷联合臭氧关节腔注射治疗膝骨关节炎阳虚寒凝证的临床疗效。方法:2018年6月至2020年6月,采用三伏贴贴敷联合臭氧关节腔注射治疗膝骨关节炎阳虚寒凝证患者20例。男8例,女12例。年龄40～65岁,中位数59岁。左膝10例,右膝6例,双膝4例。按照Kellgren-Lawrence分级标准,Ⅰ级10膝、Ⅱ级14膝。病程3个月至9年,中位数66个月。分别于治疗前和治疗结束后5周,采用酶联免疫吸附法测定膝关节液中白细胞介素(interleukin,IL)-1β、肿瘤坏死因子(tumor necrosis factor,TNF)-α和基质金属蛋白酶(matrix metalloproteinase,MMP)-13的含量,采用膝部疼痛视觉模拟量表(visual analogue scale,VAS)和西安大略和麦克马斯特大学(Western Ontario and McMaster Universities,WOMAC)骨关节炎指数评价临床疗效。结果:所有患者均完成治疗及疗效评价。治疗结束后5周,患者膝关节液中IL-1β、TNF-α、MMP-13的含量及膝部疼痛VAS评分、WOMAC骨关节炎指数均低于治疗前[(8.75±2.83)ng·L-1,(3.72±2.21)ng·L-1,t=6.252,P=0.000;(89.51±11.76)ng·L-1,(41.83±7.85)ng·L-1,t=15.081,P=0.000;(4.06±1.23)ng·L-1,(2.03±0.67)ng·L-1,t=6.482,P=0.000;(5.63±1.21)分,(2.16±1.09)分,t=9.592,P=0.000;(40.28±13.12)分,(17.14±9.87)分,t=6.303,P=0.000]。结论:三伏贴贴敷联合臭氧关节腔注射治疗膝骨关节炎阳虚寒凝证,能够抑制炎症反应和软骨基质降解,缓解疼痛,改善膝关节功能。

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备注/Memo

备注/Memo:
基金项目:厦门市医疗卫生项目(3502Z20189065)
通讯作者:林涛 E-mail:417403173@qq.com
更新日期/Last Update: 1900-01-01