[1]李明,周富根,曹武,等.氨基葡萄糖联合塞来昔布口服治疗膝骨关节炎的临床疗效系统评价[J].中医正骨,2019,31(07):34-36.
　LI Ming,ZHOU Fugen,CAO Wu,et al.Clinical curative effects of oral applications of glucosamine and celecoxib for treatment of knee osteoarthritis:a systematic review[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2019,31(07):34-36.
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氨基葡萄糖联合塞来昔布口服治疗膝骨关节炎的临床疗效系统评价()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期数:
2019年07期
页码:
34-36
栏目:
文献研究
出版日期:
2019-07-20

文章信息/Info

Title:
Clinical curative effects of oral applications of glucosamine and celecoxib for treatment of knee osteoarthritis:a systematic review
作者:
李明; 周富根; 曹武; 姚峰; 周宏毓; 肖坚
(嘉善县第一人民医院,浙江 嘉善 314100)
Author(s):
LI Ming; ZHOU Fugen; CAO Wu; YAO Feng; ZHOU Hongyu; XIAO Jian
The First People's Hospital of Jiashan County,Jiashan 314100,Zhejiang,China
关键词:
骨关节炎; 膝;  药物疗法; 联合;  Meta分析;  氨基葡萄糖;  塞来昔布
Keywords:
osteoarthritis; knee;  drug therapy; combination;  meta-analysis;  glucosamine;  celecoxib
摘要:
目的:对氨基葡萄糖联合塞来昔布口服治疗膝骨关节炎(knee osteoarthritis,KOA)的临床疗效进行系统评价。方法:通过计算机检索中国知网、中国生物医学文献数据库、维普医药信息资源系统、万方数据库、PubMed及EMBase数据库从1995年1月至2018年12月收录的有关氨基葡萄糖联合塞来昔布口服(治疗组)和单纯塞来昔布口服(对照组)治疗KOA的随机对照临床研究文献,筛选文献、提取资料,并采用Jadad量表对文献质量进行评价后,进行Meta分析。结果:初检共检索到相关文献94篇,筛选后最终纳入文献9篇,均为中文文献。纳入文献均为单中心随机对照临床试验,共纳入KOA患者882例。9篇文献Jadad量表评分均≤2分,文献质量偏低。Meta分析结果显示,治疗组治疗有效率高于对照组[OR=8.51,95%CI(4.10,17.64)],治疗后患膝Lequesne骨关节炎严重度指数和疼痛视觉模拟量表评分均低于对照组[WMD=-1.59,95%CI(-2.16,-1.03); WMD=-1.55,95%CI(-2.27,-0.83)]。结论:氨基葡萄糖联合塞来昔布口服是治疗KOA的有效方法,其疗效优于单纯塞来昔布口服。但由于研究所纳入的文献质量不高,该疗法的疗效还需多中心、大样本的临床随机对照试验进一步证实。
Abstract:
Objective:To systematically review the clinical curative effects of oral applications of glucosamine and celecoxib for treatment of knee osteoarthritis(KOA).Methods:All the randomized controlled trial(RCT)articles about combination therapy of oral applications of glucosamine and celecoxib(treatment group)versus monotherapy of oral application of celecoxib(control group)for treatment of KOA included from January 1995 to December 2018 were retrieved from China national knowledge internet,Chinese biomedical literature database,VMIS,WanFang Database,PubMed and EMBase Database through computer.The RCT articles were screened and the information was extracted.The methodological quality of research in the articles was evaluated by using Jadad scale and a Meta-analysis was conducted.Results:Ninety-four articles were searched out.After screening,9 Chinese single-center RCT articles(882 patients with KOA)were included in the final analysis.The Jadad scores of the 9 articles were≤2 points,and it suggested that the quality of these articles was poor.The results of Meta-analysis demonstrated that the effective rates were higher and the posttreatment Lequesne knee osteoarthritis severity index and pain visual analogue scale scores were lower in treatment group compared to control group(OR=8.51,95%CI(4.10,17.64); WMD=-1.59,95%CI(-2.16,-1.03); WMD=-1.55,95%CI(-2.27,-0.83)).Conclusion:The combination therapy of oral applications of glucosamine and celecoxib is an effective method for treatment of KOA,and it surpasses the monotherapy of oral application of celecoxib in the clinical curative effect.However,its clinical curative effect need to be further verified by multi-center,large sample,high-quality RCTs.

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备注/Memo

备注/Memo:
(收稿日期:2019-02-19 本文编辑:杨雅)
更新日期/Last Update: 2019-07-20