[1]曹嘉,周琦,钱齐荣.针灸联合玻璃酸钠关节腔注射与单纯玻璃酸钠关节腔注射治疗膝骨关节炎的临床疗效系统评价[J].中医正骨,2019,31(03):33-37.
　CAO Jia,ZHOU Qi,QIAN Qirong.Clinical curative effect of combination therapy of acupuncture and intra-articular injection of sodium hyaluronate versus monotherapy of intra-articular injection of sodium hyaluronate for treatment of knee osteoarthritis:a systematic review[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2019,31(03):33-37.
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针灸联合玻璃酸钠关节腔注射与单纯玻璃酸钠关节腔注射治疗 膝骨关节炎的临床疗效系统评价()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期数:
2019年03期
页码:
33-37
栏目:
文献研究
出版日期:
2019-03-20

文章信息/Info

Title:
Clinical curative effect of combination therapy of acupuncture and intra-articular injection of sodium hyaluronate versus monotherapy of intra-articular injection of sodium hyaluronate for treatment of knee osteoarthritis:a systematic review
作者:
曹嘉; 周琦; 钱齐荣
(上海长征医院,上海 200003)
Author(s):
CAO Jia; ZHOU Qi; QIAN Qirong
Shanghai Changzheng Hospital, Shanghai 200003,China
关键词:
骨关节炎; 膝;  针刺疗法;  注射; 关节内;  透明质酸;  Meta分析
Keywords:
osteoarthritis; knee;  acupuncture therapy;  injections; intra-articular;  hyaluronic acid;  meta-analysis
摘要:
目的:系统评价针灸联合玻璃酸钠关节腔注射与单纯玻璃酸钠关节腔注射治疗膝骨关节炎的临床疗效。方法:通过计算机检索中国知网、万方医学网、重庆维普、美国医学文摘和Cochrane临床对照试验中心注册库(2018年第1期)等数据库从建库至2018年3月15日,关于针灸联合玻璃酸钠关节腔注射与单纯玻璃酸钠关节腔注射治疗膝骨关节炎临床疗效比较的文献,进行Meta分析。结果:初检共检出相关文献231篇,依据文献纳入和排除标准筛选后,最终纳入9篇文献进行分析,均为中文文献。纳入的9篇文献均为单中心随机对照临床试验; 8篇文献描述了随机分组方法,1篇文献仅描述随机分组,未提及随机分组方法; 1篇文献描述了在分组时采用了单盲的方法,均未提及患者盲法; 9篇文献均未提及结果评估者盲法; 9篇文献均有明确的诊断标准及疗效评价标准。9篇文献均计算了两种疗法的近期临床治疗有效率,并进行了比较,各项研究间异质性较小(I2=0%),采用固定效应模型分析,针灸联合玻璃酸钠关节腔注射治疗膝骨关节炎近期临床治疗有效率高于单纯玻璃酸钠关节腔注射[RR=1.16,95%CI(1.10,1.22)]。9篇文献的发表偏倚较小。结论:针灸联合玻璃酸钠关节腔注射治疗膝骨关节炎的近期临床疗效优于单纯玻璃酸钠关节腔注射。
Abstract:
Objective:To systematically review the clinical curative effect of combination therapy of acupuncture and intra-articular injection of sodium hyaluronate versus monotherapy of intra-articular injection of sodium hyaluronate for treatment of knee osteoarthritis(KOA).Methods:All the articles about clinical curative effects of combination therapy of acupuncture and intra-articular injection of sodium hyaluronate versus monotherapy of intra-articular injection of sodium hyaluronate for treatment of KOA included from database establishing to March 15,2018 were retrieved from China national knowledge internet,WanFang Data,VIP Database,Medline and Cochrane Central Register of Controlled Trials(2018,No.1)through computer,and a Meta-analysis was conducted.Results:Two hundred and thirty-one articles were searched out in the initial stage.After screening according to inclusion and exclusion criteria,9 Chinese single-center randomized controlled trial(RCT)articles were included in the final analysis,including 8 articles in which randomization method was described and 1 article in which only randomization was described and the method of randomization was not mentioned.Meanwhile,the single blind method used for grouping was described in 1 article while the blind method used for patients and outcome assessors was not mentioned in all of the 9 articles.Clear diagnostic criteria and curative effect evaluation criteria were described and the short-term clinical effective rate was evaluated and compared between the two therapies in all of the 9 articles.The minor heterogeneity was found between the studies(I2=0%),and a Meta-analysis was conducted by using fixed effect model.The result of Meta-analysis demonstrated that the short-term clinical curative effective rate of combination therapy of acupuncture and intra-articular injection of sodium hyaluronate was higher than that of monotherapy of intra-articular injection of sodium hyaluronate in treatment of KOA(RR=1.16,95%CI(1.10,1.22)),and the publication bias of the 9 articles was not obvious.Conclusion:Combination therapy of acupuncture and intra-articular injection of sodium hyaluronate surpasses monotherapy of intra-articular injection of sodium hyaluronate in short-term clinical curative effect in treatment of KOA.

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备注/Memo

备注/Memo:
基金项目:上海申康医院发展中心临床科技创新项目(SHDC12015320) 通讯作者:钱齐荣 E-mail:qianqr@smmu.edu.cn(收稿日期:2018-12-03 本文编辑:杨雅)
更新日期/Last Update: 2019-03-30