[1]许丽梅,贾良良,何晓娟,等.环状RNA在骨关节炎发生发展中的作用[J].中医正骨,2018,30(07):39-42.
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环状RNA在骨关节炎发生发展中的作用()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第30卷
期数:
2018年07期
页码:
39-42
栏目:
综 述
出版日期:
2018-07-20

文章信息/Info

作者:
许丽梅1贾良良1何晓娟1李慧1叶蕻芝2李西海1
(1.福建中医药大学,福建 福州 350108; 2.福建省中西医结合老年性疾病重点实验室,福建 福州 350108)
关键词:
骨关节炎 RNA 综述
摘要:
骨关节炎是一种常见的慢性、退行性、进展性骨关节疾病,为力学因素与生物学因素共同作用下导致软骨细胞、细胞外基质和软骨下骨三者降解-合成正常偶联失衡的结果。环状RNA(circular RNA,circRNA)是一类具有环形结构的RNA分子,在多种生物体中广泛存在,并在多种疾病中发挥特殊的生物学功能,但其在骨关节炎发生发展中的作用机制有待进一步深入研究。本文从circRNA的生物学功能以及circRNA调控炎症反应、软骨基质代谢、软骨下骨的改变与软骨细胞增殖、分化、凋亡等方面对circRNA在骨关节炎发生发展中的作用进行了综述。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(81573998); 福建省自然科学基金科技计划项目(2016J01395); 中国博士后科学基金第60批面上资助项目(2016M600625); 中国博士后科学基金第10批特别资助项目(2017T100591) 通讯作者:李西海 E-mail:lixihai79dahai@163.com
更新日期/Last Update: 2018-11-30