[1]王伟东,陈如平,肖鲁伟,等.雷公藤甲素对类风湿关节炎滑膜新生血管中 血管内皮生长因子、白细胞介素-6抑制机理的探讨[J].中医正骨,2012,24(02):3-5.
　WANG Wei-dong*,CHEN Ru-ping,XIAO Lu-wei,et al.Inhibitory mechanism of Triptolide on the expression of VEGF,IL-6 in rheumatoid arthritis synovial membrane newborn blood vessel[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(02):3-5.
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雷公藤甲素对类风湿关节炎滑膜新生血管中 血管内皮生长因子、白细胞介素-6抑制机理的探讨()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第24卷
期数:
2012年02期
页码:
3-5
栏目:
基础研究
出版日期:
2012-02-25

文章信息/Info

Title:
Inhibitory mechanism of Triptolide on the expression of VEGF,IL-6 in rheumatoid arthritis synovial membrane newborn blood vessel
作者:
王伟东; 陈如平; 肖鲁伟; 王昌兴; 成锋
浙江中医药大学附属第二医院,浙江 杭州 310005
Author(s):
WANG Wei-dong*; CHEN Ru-ping; XIAO Lu-wei; WANG Chang-xing; CHENG Feng.*
The affiliated No.2 hospital of Zhejiang TCM university,Hangzhou 310005,Zhejiang,China
关键词:
雷公藤内脂 关节炎; 类风湿 血管内皮生长因子类 白细胞介类类 动物实验
Keywords:
Triptolide;  Rheumatoid arthritis;  Angiogenesis;  Immunohistochemistry
摘要:
目的:了解雷公藤甲素对类风湿关节炎中血管内皮生长因子、白细胞介素-6的影响,探讨雷公藤对类风湿关节炎患者滑膜新生血管的抑制机理。方法:应用免疫组化技术检测血管内皮生长因子、白细胞介素-6在AA大鼠踝关节滑膜组织中的表达,并观察了雷公藤对其的影响。 结果:雷公藤组可见少量的血管内皮生长因子阳性细胞,与对照组比较差异有统计学意义(P<0.01)。大鼠滑膜关节腔滑液中白细胞介素-6水平检测中,实验显示对照组滑膜组织中白细胞介素-6的水平明显高于空白组和雷公藤组(P<0.01)。结论:雷公藤甲素能降低滑膜组织血管内皮生长因子、白细胞介素-6的表达水平,抑制血管生成。
Abstract:
Objective:To investigate the effect and inhibitory mechanisms of Triptolide on VEGF,IL-6 in rheumatoid arthritis synovial membrane newborn blood vessel.Methods:Use immunohistochemical techniques to detect expression of VEGF,IL-6 in the AA rats in the organization of the synovial organization,and to observe the effects of tripterygium wilfordii on the expression of VEGF,IL-6.Results:VEGF positive cells were visible in the tripterygium wilfordii group,there was significant difference(P<0.01)compared with the experimental group.In the rat synovial articular cavity synovial fluid IL-6 level detection,IL-6 level in the experimental group synovial organization is significantly higher than the level of blank and tripterygium wilfordii group (P<0.01).Conclusion:Triptolide can reduce the expression of VEGF and IL-6 in synovial organizations and inhibit angiogenesis.

参考文献/References:

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备注/Memo

备注/Memo:
2011-01-09收稿 2011-10-23修回
基金项目:2008年浙江省中医药青年课题资助项目(2008YA010)
更新日期/Last Update: 2012-02-25