[1]李泾,李尚佳,张昱韬,等.中医药调控Piezo1信号通路防治膝骨关节炎的研究进展[J].中医正骨,2026,38(03):59-65.
 LI Jing,LI Shangjia,ZHANG Yutao,et al.Advances in research on traditional Chinese medicine regulating the Piezo1 signaling pathway for prevention and treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2026,38(03):59-65.
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中医药调控Piezo1信号通路防治膝骨关节炎的研究进展()

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第38卷
期数:
2026年03期
页码:
59-65
栏目:
综述
出版日期:
2026-03-20

文章信息/Info

Title:
Advances in research on traditional Chinese medicine regulating the Piezo1 signaling pathway for prevention and treatment of knee osteoarthritis
作者:
李泾1李尚佳2张昱韬2张昊翔2袁普卫1
(1.陕西中医药大学中西医结合学院,陕西 咸阳 712046; 2.陕西中医药大学附属医院,陕西 咸阳 712000)
Author(s):
LI JingLI ShangjiaZHANG YutaoZHANG HaoxiangYUAN Puwei
关键词:
骨关节炎 中医药疗法 针刺 中药 复方(中药) 信号传导 离子通道 Piezo1 综述
摘要:
膝骨关节炎(knee osteoarthritis,KOA)是以关节软骨退变为核心的慢性退行性疾病,机械应力异常在其发生发展中发挥关键作用。机械敏感性离子通道Piezo1作为软骨细胞感知力学刺激的关键分子,可将异常力学刺激转化为细胞内钙信号,激活下游相关信号通路,进而引发炎症反应、细胞外基质降解、细胞死亡等一系列病理过程,是连接关节力学负荷异常与软骨退变的重要分子枢纽。中医药防治KOA具有独特优势,近年来其在调控Piezo1信号通路方面的作用机制日益受到关注。研究表明,中医药通过调控Piezo1信号通路,能够有效抑制异常机械应力诱导的软骨损伤,从而维持关节软骨代谢稳态、延缓关节软骨退变。本文概述了Piezo1信号通路,阐述了该通路在KOA发生发展中的作用,对中医药调控Piezo1信号通路防治KOA的研究进展进行了综述,为KOA的防治提供了参考。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(82474348); 全国名老中医药专家传承工作室建设项目(国中医药人教函〔2018〕134号); 陕西省教育厅重点科学研究计划项目(24JR056); 陕西省中医药管理局第二批中医药重点研究室建设项目(陕中医药发〔2018〕32号); 陕西省中医学术流派传承工作室(建设)项目(陕中医药发〔2018〕40号); 陕西中医药大学学科创新团队项目(2019YL02)
通信作者:袁普卫 E-mail:spine_surgeon@163.com
(收稿日期:2026
更新日期/Last Update: 2026-03-20