[1]杨虎,郑宇,王通,等.铜死亡在骨关节炎发生发展中的作用机制及铜靶向治疗策略的应用前景[J].中医正骨,2025,37(08):51-55.
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铜死亡在骨关节炎发生发展中的作用机制及铜靶向治疗策略的应用前景()

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第37卷
期数:
2025年08期
页码:
51-55
栏目:
综述
出版日期:
2025-08-20

文章信息/Info

作者:
杨虎1郑宇2王通1张广飞1纪垚垚1
1.陕西中医药大学,陕西 咸阳 712046; 2.陕西省中医医院,陕西 西安 710003
关键词:
骨关节炎 铜死亡 铜代谢 综述
摘要:
骨关节炎(osteoarthritis,OA)是一种高发于中老年人群的慢性退行性关节疾病,其发病与铜死亡关系密切。铜死亡作为一种新发现的程序性细胞死亡形式,通过铜离子直接结合线粒体三羧酸循环中的硫辛酰化蛋白,引发铁硫蛋白降解和蛋白质毒性应激,最终导致细胞死亡。目前,关于铜死亡在OA发生发展中的具体作用机制尚不清楚。本文概述了铜死亡,阐述了铜死亡在OA发生发展中的作用机制,展望了铜靶向治疗策略在OA治疗中的应用前景,为OA的诊疗提供了新的理论依据和研究思路。

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备注/Memo

备注/Memo:
基金项目:陕西省中医药管理局科研课题(2019-GJ-JC011)
通讯作者:郑宇 E-mail:sxszyyygskzy@163.com
更新日期/Last Update: 1900-01-01