[1]徐文博,汪利合,刘林枫,等.针刀干预对膝骨关节炎模型兔影响的Meta分析[J].中医正骨,2023,35(08):43-50.
　XU Wenbo,WANG Lihe,LIU Linfeng,et al.Effects of acupotomy intervention on model rabbits with knee osteoarthritis:a meta-analysis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2023,35(08):43-50.
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针刀干预对膝骨关节炎模型兔影响的Meta分析()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第35卷
期数:
2023年08期
页码:
43-50
栏目:
文献研究
出版日期:
2023-08-20

文章信息/Info

Title:
Effects of acupotomy intervention on model rabbits with knee osteoarthritis:a meta-analysis
作者:
徐文博1; 汪利合2; 刘林枫1; 张文欣1
1.河南中医药大学骨伤学院,河南 郑州 450002; 2.河南中医药大学第一附属医院,河南 郑州 450000
Author(s):
XU Wenbo1; WANG Lihe2; LIU Linfeng1; ZHANG Wenxin1
1.College of Orthopaedics and Traumatology of Henan University of Chinese Medicine,Zhengzhou 450002,Henan,China 2.The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China
关键词:
骨关节炎; 膝;  针刀疗法;  动物实验;  兔;  专题Meta分析
Keywords:
osteoarthritis; knee;  acupotomy therapy;  animal experimentation;  rabbits;  meta-analysis as topic
摘要:
目的:系统评价针刀干预对膝骨关节炎(knee osteoarthritis,KOA)模型兔的影响,探讨针刀治疗KOA的可能的作用机制。方法:应用计算机检索中国知网、万方数据库、维普网、中国生物医学文献服务系统、PubMed、Web of Science、Cochrane Library、Embase,收集针刀干预KOA模型兔的随机对照动物实验,检索时限均为建库至2022年10月21日。实验组采用针刀疗法干预,对照组不进行任何干预。由2名研究者独立筛选文献、提取数据并评价纳入研究的偏倚风险,采用RevMan5.3软件进行Meta 分析。采用STATA14.0软件进行Bgger's检验,评价发表偏倚。结果:最终纳入17项研究,涉及258只KOA模型兔,实验组和对照组各129只。Meta分析结果显示,针刀干预后实验组的Lequesne MG评分、Mankin评分、软骨细胞凋亡率、关节液白细胞介素(interleukin,IL)-6表达水平、关节液肿瘤坏死因子-α表达水平均低于对照组[MD=-3.05,95%CI(-4.05,-2.05),P=0.000; MD=-3.95,95%CI(-4.86,-3.04),P=0.000; SMD=-3.81,95%CI(-5.79,-1.84),P=0.000; SMD=-1.99,95%CI(-2.83,-1.16),P=0.000; SMD=-4.22,95%CI(-7.43,-1.01),P=0.010],2组关节液IL-1表达水平的差异无统计学意义[SMD=-22.98,95%CI(-64.60,18.65),P=0.280]。基于Mankin评分进行发表偏倚分析,Bgger's检验显示不存在发表偏倚(P=0.074)。结论:现有的证据表明,针刀干预能够减轻KOA模型兔膝关节疼痛与肿胀、改善膝关节功能和软骨组织病理学形态,其作用可能与减少软骨细胞凋亡、抑制相关促炎症细胞因子表达有关。
Abstract:
Objective:To systematically review the effects of acupotomy intervention on model rabbits with knee osteoarthritis(KOA),and to explore the possible mechanisms of acupotomy in treatment of KOA.Methods:All the articles about intervention on KOA model rabbits with acupotomy included from database establishing to October 21,2022 were retrieved from China National Knowledge Internet,Wanfang Database,Vip Database,Chinese Biomedical Literature Service System,PubMed,Web of Science,Cochrane Library and Embase through computer.The rabbits in experiment group were intervened by acupotomy therapy,while the ones in control group were not given any intervention.The articles were screened and the information was extracted independently by two researchers.The risk of bias of included researches was assessed and a Meta-analysis was conducted by using RevMan5.3 software.Furthermore,the Bgger's test was performed by using STATA14.0 software,and the publication bias was evaluated.Results:Seventeen articles(258 KOA model rabbits)were included in the final analysis,129 KOA model rabbits in each group.The results of Meta-analysis revealed that the Lequesne MG score,Mankin score,chondrocyte apoptosis rate,the expression levels of interleukin(IL)-6 and tumor necrosis factor-α in knee synovial fluid were all lower in experiment group compared to control group after acupotomy intervention(MD=-3.05,95%CI(-4.05,-2.05),P=0.000; MD=-3.95,95%CI(-4.86,-3.04),P=0.000; SMD=-3.81,95%CI(-5.79,-1.84),P=0.000; SMD=-1.99,95%CI(-2.83,-1.16),P=0.000; SMD=-4.22,95%CI(-7.43,-1.01),P=0.010),however,there was no statistical difference in the expression level of IL-1 in knee synovial fluid between the 2 groups(SMD=-22.98,95%CI(-64.60,18.65),P=0.280).Publication bias was analyzed based on the Mankin scores,and the results of Bgger's test showed that there was no publication bias in the included articles(P=0.074).Conclusion:Available evidences suggest that the acupotomy intervention can reduce knee pain and swelling,improve knee function and histopathologic form of cartilage tissues in model rabbits with KOA possibly by reducing the apoptosis of chondrocytes and inhibiting the expression of related pro-inflammatory cytokines.

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备注/Memo

备注/Memo:
基金项目:河南省中医药拔尖人才培养项目(豫中医科教〔2018〕35号) 通讯作者:汪利合 E-mail:wanglihe0222@sina.com
更新日期/Last Update: 1900-01-01