参考文献/References:
[1] 陈孝平,汪建平,赵继宗.外科学[M].9版.北京:人民卫生出版,2018:761.
[2] 马玉环,郑文伟,林平冬,等.骨关节炎软骨退变与炎症的关系[J].风湿病与关节炎,2015,4(8):50-53.
[3] 陈世宣,刘益杰,胡笑燊,等.基于瞬时受体电位香草素亚家族4信号通路探讨牛蒡子苷元对体外培养软骨细胞增殖及 Ⅱ 型胶原蛋白和软骨蛋白聚糖表达的影响[J].中医正骨,2017,29(10):13-19.
[4] SUN S H,DONG X Z.Trp channels and itch[J].Semin Immunopathol,2016,38(3):293-307.
[5] ALONSO-CARBAJO L,KECSKES M,JACOBS G,et al.Muscling in on TRP channels in vascular smooth muscle cells and cardiomyocytes[J].Cell Calcium,2017,66:48-61.
[6] 吴静,程全艺,杨梦成,等.TRPV4通道及其与疾病关系的研究进展[J].生命的化学,2018,38(6):809-814.
[7] VAN DER EERDEN B C J,OEI L,ROSCHGER P,et al.TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk[J].Bone,2013,57(2):443-454.
[8] HINES S L,RICHTER Jr J E,MOHAMMAD A N,et al.Protein informatics combined with multiple data sources enriches the clinical characterization of novel TRPV4 variant causing an intermediate skeletal dysplasia[J].Mol Genet Genomic Med,2019,7(3):e566.
[9] 艾健,王春林,罗志红,等.从肌肉力学及软骨细胞层面探讨推拿治疗膝骨关节炎的研究[J].辽宁中医杂志,2020,47(1):65-67.
[10] GRACE M S,BONVINI S J,BELVISI M G,et al.Modulation of the TRPV4 ion channel as a therapeutic target for disease[J].Pharmacol Ther,2017,177:9-22.
[11] 胡笑燊,丁道芳,张增乔,等.牛蒡子苷元基于机械敏感离子通道对软骨细胞转录因子和胶原蛋白表达的影响[J].上海中医药大学学报,2020,34(1):69-76.
[12] LEFEBVRE V,DVIR-GINZBERG M.SOX9 and the many facets of its regulation in the chondrocyte lineage[J].Connect Tissue Res,2017,58(1):2-14.
[13] MCNULTY A L,LEDDY H A,LIEDTKE W,et al.TRPV4 as a therapeutic target for joint diseases[J].Naunyn Schmiedebergs Arch of Pharmacology,2015,388(4):437-450.
[14] 姚旺祥,戴晗豪,董佩龙,等.TRPV4在骨关节炎与正常软骨中的表达差异及意义[J].中国修复重建外科杂志,2020,34(1):63-68.
[15] GUILAK F,LEDDY H A,LIEDTKE W.Transient receptor potential vanilloid 4:the sixth sense of the musculoskeletal system?[J].Ann N Y Acad Sci,2010,1192:404-409.
[16] SADOWSKA A,KAMEDA T,KRUPKOVA O,et al.Osmosensing,osmosignalling and inflammation:how intervertebral disc cells respond to altered osmolarity[J].Eur Cell Mater,2018,36:231-250.
[17] XI Y,HUANG X J,TAN G M,et al.Protective effects of Erdosteine on interleukin-1β-stimulated inflammation via inhibiting the activat ion of MAPK,NF-κB,and Wnt/β-catenin signaling pathways in rat osteoarthritis[J].Eur J Pharmacol,2020,873:172925.
[18] 张力,王培民,殷松江,等.TRPV4通道在膝骨关节炎软骨细胞中的功能表达[J].中国现代医学杂志,2019,29(23):17-22.
[19] KOBAYAKAWA T,TAKAHASHI N,SOBUE Y,et al.Mechanical stress loading induces CD44 cleavage in human chondrocytic HCS-2/8 cells[J].Biochem Biophys Res Commun,2016,478(3):1230-1235.
[20] LV M X,ZHOU Y L,CHEN X Y,et al.Calcium signaling of in situ chondrocytes in articular cartilage under compressive loading:roles of calcium sources and cell membrane ion channels[J].J Orthop Res,2018,36(2):730-738.
[21] MARSHALL C B,NISHIKAWA T,OSAWA M,et al.Calmodulin and STIM proteins:two major calcium sensors in the cytoplasm and endoplasmic reticulum[J].Biochem Biophys Res Commun,2015,460(1):5-21.
[22] PAPOFF G,TRIVIERI N,CRIELESI R,et al.FADD-calmodulin interaction:a novel player in cell cycle regulation[J].Biochim Biophys Acta,2010,1803(8):898-911.
[23] XU B,XING R L,HUANG Z Q,et al.Excessive mechanical stress induces chondrocyte apoptosis through TRPV4 in an anterior cruciate ligament-transected rat osteoarthritis model[J].Life Sci,2019,228:158-166.
[24] DENADAI-SOUZA A,MARTIN L,DE PAULA M A,et al.Role of transient receptor potential vanilloid 4 in rat joint inflammation[J].Arthritis Rheum,2012,64(6):1848-1858.
[25] ITOH Y,HATANO N,HAYASHI H,et al.An environmental sensor,TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes[J].Am J Physiol Cell Physiol,2009,297(5):C1082-C1090.
[26] PRITCHARD S,GUILAK F.Effects of interleukin-1 on calcium signaling and the increase of filamentous actin in isolated and in situ articular chondrocytes[J].Arthritis Rheum,2006,54(7):2164-2174.
[27] PHAN M N,LEDDY H A,VOTTA B J,et al.Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes[J].Arthritis Rheum,2009,60(10):3028-3037.
[28] PRITCHARD S,VOTTA B J,KUMAR S,et al.Interleukin-1 inhibits osmotically induced calcium signaling and volume regulation in articular chondrocytes[J].Osteoarthritis Cartilage,2008,16(12):1466-1473.
[29] 叶东,张海峰,朱林燕,等.ClC-3 siRNA抑制鼻咽癌细胞调节性容积回缩[J].南方医科大学学报,2011,31(2):216-220.
[30] 赵凌睿.基于TRPV1和TRPV4钙离子通道对“易层”贴敷外治膝骨关节炎中滑膜炎症机械性痛觉过敏的研究[D].南京:南京中医药大学,2018.
[31] HINATA M,IMAI S,SANAKI T,et al.Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-ep oxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis[J].Pain,2018,159(5):939-947.
[32] VON BANCHET G S,BOETTGER M K,KÖNIG C,et al.Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia[J].Mol Cell Neurosci,2013,52:152-160.
[33] XING R L,WANG P M,ZHAO L R,et al.Mechanism of TRPA1 and TRPV4 participating in mechanical hyperalgesia of rat experimental knee osteoarthritis[J].Arch Rheumatol,2017,32(2):96-104.
[34] CLARK A L,VOTTA B J,KUMAR S,et al.Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4:age-and sex-dependent progression of osteoarthritis in Trpv4-deficient mice[J].Arthritis Rheum,2010,62(10):2973-2983.
相似文献/References:
[1]孟维娜,明立功,王新德,等.关节镜下清理联合腓骨近1/3段截骨治疗膝骨关节炎[J].中医正骨,2015,27(11):40.
[2]明立功,孟维娜,王新德,等.腓骨近端截骨治疗内侧间室膝骨关节炎的近期疗效观察[J].中医正骨,2015,27(10):25.
[3]张杰,王人彦,张玉柱.膝骨关节炎的治疗进展[J].中医正骨,2015,27(10):68.
[4]梁朝,蔡静怡,闫立,等.针刀疗法改善膝骨关节炎早期疼痛症状的疗效评价[J].中医正骨,2015,27(09):9.
LIANG Zhao,CAI Jingyi,YAN Li,et al.Evaluation of the curative effect of needle-knife therapy for relieving knee pain in patients with early knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(08):9.
[5]王建武,党建军,李强,等.四联疗法治疗膝骨关节炎[J].中医正骨,2015,27(08):44.
[6]刘红娟,郭会利,郭树农.云克联合中药治疗膝骨关节炎的护理[J].中医正骨,2015,27(08):75.
[7]陈卫衡.探索建立系统的膝骨关节炎中医临床科研范式
和理论体系[J].中医正骨,2015,27(07):1.
[8]郑春松,叶蕻芝,李西海,等.透骨消痛胶囊中补肾柔肝药和活血祛风药治疗
骨关节炎作用方式的计算机模拟比较[J].中医正骨,2015,27(07):6.
ZHENG Chunsong,YE Hongzhi,LI Xihai,et al.Comparison of the mode of action of Bushen Rougan(补肾柔肝)drugs versus Huoxue Qufeng(活血祛风)drugs contained in Tougu Xiaotong Jiaonang(透骨消痛胶囊)for the treatment of osteoarthritis:A computer simulation study[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(08):6.
[9]帅波,沈霖,杨艳萍,等.加味青娥丸治疗膝骨关节炎的作用机制研究[J].中医正骨,2015,27(07):15.
SHUAI Bo,SHEN Lin,YANG Yanping,et al.Study on the mechanism of action of Jiawei Qing'e Wan(加味青娥丸)for the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(08):15.
[10]梅其杰,袁长深,段戡,等.壮药骨痹方烫熨联合运动疗法治疗膝骨关节炎的临床研究[J].中医正骨,2015,27(07):27.
MEI Qijie,YUAN Changshen,DUAN Kan,et al.Clinical study of the curative effect of hot compressing and rubbing with packet of Gubi Fang(骨痹方)combined with exercise therapy in the treatment of knee osteoarthritis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(08):27.