[1]王战朝,杜志谦,闫永昌,等.通经活利汤治疗膝关节滑膜炎的临床研究[J].中医正骨,2012,24(04):26-29.
　WANG Zhan-chao*,DU Zhi-qian,YAN Yong-chang,et al.Clinical study on the curative effect and safety of TONGJING HUOLI decoction in knee synovitis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2012,24(04):26-29.
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通经活利汤治疗膝关节滑膜炎的临床研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第24卷
期数:
2012年04期
页码:
26-29
栏目:
临床研究
出版日期:
2012-04-30

文章信息/Info

Title:
Clinical study on the curative effect and safety of TONGJING HUOLI decoction in knee synovitis
作者:
王战朝1; 杜志谦1; 闫永昌2; 张晓强1; 尚延春1; 孟庆阳1
1.河南省洛阳正骨医院,河南 洛阳 471002;
2.郑州大学医学院,河南 郑州 450001
Author(s):
WANG Zhan-chao*; DU Zhi-qian; YAN Yong-chang; ZHANG Xiao-qiang; SHANG Yan-chun; MENG Qing-yang.*
Luoyang Orthopedic-Traumatological Hospital,Luoyang 471002,Henan,China
关键词:
滑膜炎 膝关节 通经活利汤 消炎药; 非甾类 治疗; 临床研究性
Keywords:
Synovitis;  Knee joint;  TONGJING HUOLI DECOCTION;  Anti-inflammatory agents; non-steroidal;  Therapies; investigational
摘要:
目的:观察通经活利汤治疗膝关节滑膜炎的临床疗效和安全性。方法:采用随机数字表将符合要求的220例膝关节滑膜炎患者随机分为2组,实验组120例,对照组100例。实验组患者采用通经活利汤治疗,对照组患者口服萘丁美酮胶囊,治疗28 d后按照自拟的症状体征分级量化评分表对2组患者进行疗效评定,同时观察记录2组患者治疗期间发生胃肠道反应的情况。结果:①临床疗效。实验组临床疗效优于对照组(Z=-8.992,P=0.000)。②安全性。在治疗期间实验组1例出现胃肠道反应,对照组16例出现胃肠道反应,实验组不良反应发生率低于对照组(χ2=17.597,P=0.000)。结论:通经活利汤能明显减轻膝关节滑膜炎患者膝的临床症状,改善膝关节功能,其疗效优于萘丁美酮胶囊,而且不良反应也较非甾体类抗炎药少。
Abstract:
Objective:To observe the curative effect and safety of TONGJING HUOLI decoction in knee synovitis.Methods:Two hundred and twenty patients with knee synovitis were randomly divided into 2 groups,120 cases in the experimental group,while the others in the control group.Patients in the experimental group were administrated with TONGJING HUOLI decoction,while the others in the control group were administrated with Nabumetone capsules.After 28 days treatment,the curative effects were evaluated according to the self-designed scoring scale of signs and symptoms.Meantime,the gastrointestinal reactions of patients occurred during the treatment period were observed and recorded.Results:The clinical curative effect of experimental group was better than that of control group(Z=-8.992,P=0.000).During the treatment period,1 case with gastrointestinal reaction was found in experimental group,while 16 cases with gastrointestinal reactions were found in control group.Incidence of adverse reactions of experimental group was lower than that of control group(χ2=17.597,P=0.000).Conclusion:TONGJING HUOLI decoction can significantly relieve knee clinical symptoms for the patients with knee synovitis and enhance knee function.Furthermore,its curative effect is better than that of Nabumetone capsules,and its adverse reactions are less than that of non-steroidal anti-inflammatory drugs.

参考文献/References:

[1] 施杞,王和鸣.骨伤科学[M].北京:人民卫生出版社,2001:1041-1043.
[2] 郭维淮.洛阳平乐正骨[M].北京:人民卫生出版社,2008:758.
[3] 国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:197.
[4] 杜志谦.中医药治疗膝关节滑膜炎的研究进展[J].中医正骨,2005,17(9):72-73.
[5] 梅立鹤.中西药合用治疗膝关节慢性创伤性滑膜炎对照研究[J].中国中医骨伤科杂志,2007,15(2):17-19.
[6] 国家中医药管理局.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:349-353.
[7] 连福水.益气渗湿法中药内服配合熏洗治疗慢性膝关节滑膜炎[J].广西中医药,2011,34(4):22-23.
[8] 周昌,张曦.中医药治疗膝关节创伤性滑膜炎的进展[J].云南中医中药杂志,2011,32(1):69-70.
[9] 谢冠豪.中医药治疗膝关节创伤性滑膜炎的临床疗效[J].中国医药指南,2010,8(36):127-128.

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备注/Memo

备注/Memo:
2011-11-24收稿 2012-01-31修回
基金项目:河南省重点科技攻关项目(0623033300)
更新日期/Last Update: 2012-04-30