[1]袁尚锋.当归拈痛汤口服配合五藤散外敷治疗湿热痹阻型类风湿关节炎45例临床观察[J].中医正骨,2011,23(11):20-23.
　YUAN Shang-feng*.*.Clinical observation of Oral Danggui Niantong Decoction and Wuteng powder for 45 patients with rheumatoid arthritis of Moist Heat Arthralgia Spasm Syndrome[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2011,23(11):20-23.
点击复制

当归拈痛汤口服配合五藤散外敷治疗湿热痹阻型类风湿 关节炎45例临床观察()
分享到：

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第23卷
期数:
2011年11期
页码:
20-23
栏目:
临床研究
出版日期:
2011-11-30

文章信息/Info

Title:
Clinical observation of Oral Danggui Niantong Decoction and Wuteng powder for 45 patients with rheumatoid arthritis of Moist Heat Arthralgia Spasm Syndrome
作者:
袁尚锋
湖南省株洲市中医伤科医院,湖南 株洲 412000
Author(s):
YUAN Shang-feng*.*
Department of Joint Surgery,Zhuzhou Chinese Traumatology Hospital,Zhuzhou 412000,Hunan,China
关键词:
类风湿关节炎 当归拈痛汤 五藤散 临床研究
Keywords:
Arthritis;  Rheumatoid;  Danggui Niantong Decoction;  Wuteng Powder;  Clinical Observation
摘要:
目的:观察当归拈痛汤口服配合五藤散外敷治疗类风湿关节炎的临床疗效及对相关免疫炎症指标的影响。方法:将90例类风湿关节炎患者随机分为两组,治疗组予当归拈痛汤口服配合五藤散外敷; 对照组用小剂量甲氨蝶呤治疗,治疗3个月后观察相关免疫炎症指标变化并进行疗效评价。结果:治疗组总有效率为91.11%,对照组总有效率为73.33%。治疗组在改善晨僵时间、关节疼痛度、关节活动度、关节肿胀度、握力方面明显优于对照组(P<0.05或P<0.01)。治疗组CRP 、ESR、RF、TNF-α、IL-6改善优于对照组(P<0.05或P<0.01)。结论:当归拈痛汤口服配合五藤散外敷能有效抑制致免疫炎症细胞因子产生和释放,改善类风湿关节炎症状体征,且无明显副作用,是治疗类风湿关节炎的有效方剂。
Abstract:
Objective:To observe the curative effect of Oral Danggui Niantong Decoction and Wuteng powder for rheumatoid arthritis and the effect on relative immunological and inflammatory markers.Methods:Totally 90 patients with rheumatoid arthritis were randomly and equally divided into two groups.Oral Danggui Niantong Decoction and Wuteng powder was used in treatment group,while small dose methotrexate in control group.The relative immunological and inflammatory markers were observed and the curative effect of both groups was evaluated after three-month's treatment.Results:The total effective rate of treatment group was 91.11% and it was superior to 73.33% of control group.Improvements of morning stiffness duration,joint pain and swell,range of motion and grip strength in treatment group were superior to that in control group(P<0.05 or P<0.01).After Oral Danggui Niantong Decoction and Wuteng powder treatment,improvements of c-reactive protein(CRP),erythrocyte sedimentation rate(ESR),rheumatoid factor(RF),and tumor necrosis factor alpha(TNF-α),interleukin 6(IL-6)were superior to that in control group(P<0.05 or P<0.01).Conclusion:Oral Danggui Niantong Decoction and Wuteng powder can remarkably inhibit the production and release of relative immunological and inflammatory markers and improve the symptoms and signs of rheumatoid arthritis with no conspicuous side effects.It is a useful formula for treating rheumatoid arthritis.

参考文献/References:

[1] Murakami M,Nishimoto N.The value of blocking IL-6 outside of rheumatoid arthritis:current perspective[J].Curr Opin Rheumatol,2011,23(3):273-277.
[2] To H,Yoshimatsu H,Tomonari M,et al.Methotrexate Chronotherapy is Effective Against Rheumatoid Arthritis[J].Chronobiol Int,2011,28(3):267-274.
[3] Strzpa A,Szczepanik M.IL-17-expressing cells as a potential therapeutic target for treatment of immunological disorders[J].Pharmacol Rep,2011,63(1):30-44.
[4] 周仲瑛.中医内科学[M].北京:中国中医药出版社,2007.
[5] 陈朝蔚,孙剑,李玉梅,等.沈氏羌活地黄汤治疗类风湿关节炎随机对照临床试验[J].中西医结合学报,2010,8(1)35:39.
[6] 董岩,王新芳,崔长军.茵陈蒿的化学成分和药理作用研究进展[J].时珍国医国药,2008,19(4):874-876.
[7] 王林丽,宋志勇.防风的研究进展[J].中国药业,2006.15(10):63-64.
[8] 陈荔炟,陈树和,刘焱文.葛根资源、化学成分和药理作用研究概况[J].时珍国医国药,2006,17(11):2305-2306.
[9] 祁立强,万丽鹤,于雪峰.当归消痹汤对类风湿性关节炎的治疗研究[J].中医药学报,2008,36(4):23-24.
[10] 宋扬文,陈忻.中药黄芩药理作用的研究进展[J].中国中医药科技,2010, 17(4):375-376.
[11] 范存伟,李珍.补中益气汤主要药物的新药理作用[J].中医中药,2005,2(15):117,128.
[12] 李晓春,赵长伟,梁运海.当归通痹汤治疗膝关节骨性关节炎30例临床观察[J].中国骨伤,2007,20(3):203-204.

更新日期/Last Update: 1900-01-01