[1]陈权,周金依,肖鲁伟,等.红景天苷调控骨关节炎相关信号通路的研究进展[J].中医正骨,2020,32(11):37-43.
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红景天苷调控骨关节炎相关信号通路的研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第32卷
期数:
2020年11期
页码:
37-43
栏目:
综 述
出版日期:
2020-11-20

文章信息/Info

作者:
陈权周金依肖鲁伟童培建吴承亮阮红峰
(浙江中医药大学第一临床医学院,浙江 杭州 310053)
关键词:
骨关节炎 红景天 红景天苷 信号传导 Toll样受体4 NF-κB 低氧诱导因子 综述
摘要:
因骨关节炎(osteoarthritis,OA)的发生发展机制尚不清楚,有效药物的开发和应用受到制约。越来越多的基础和临床研究表明,软骨细胞凋亡、炎性反应是OA发生发展的关键,而Toll样受体4(Toll-like receptor,TLR4)/核因子-κB(nuclear factor-kappa B,NF-κB)信号通路与OA软骨细胞凋亡、炎性反应相关。红景天苷可通过调控上述信号通路而发挥抗炎、抗细胞凋亡作用,减少OA带来的损伤。本文对红景天苷调控与OA相关的TLR4/NF-κB、低氧诱导因子信号通路的研究进展进行了综述,为OA的药物研究提供新的思路。

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备注/Memo

备注/Memo:
基金项目:中国博士后科学基金面上资助项目(2018M632154)
通讯作者:阮红峰 E-mail:rhf@zcmu.edu.cn
更新日期/Last Update: 2020-11-20