[1]孙晓文,陈杰,孔令俊,等.环状RNA调控骨髓间充质干细胞成骨分化的研究进展[J].中医正骨,2026,38(06):61-65.
 SUN Xiaowen,CHEN Jie,KONG Lingjun,et al.Advances in research on circular RNAs in regulating osteogenic differentiation of bone marrow mesenchymal stem cells[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2026,38(06):61-65.
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环状RNA调控骨髓间充质干细胞成骨分化的研究进展()

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第38卷
期数:
2026年06期
页码:
61-65
栏目:
综述
出版日期:
2026-06-20

文章信息/Info

Title:
Advances in research on circular RNAs in regulating osteogenic differentiation of bone marrow mesenchymal stem cells
作者:
孙晓文1陈杰2孔令俊2李兴国2唐仲海2秦浩1
1.甘肃中医药大学,甘肃 兰州 730101; 2.甘肃省中医院,甘肃 兰州 730050
Author(s):
SUN XiaowenCHEN JieKONG LingjunLI XingguoTANG ZhonghaiQIN Hao
关键词:
间质干细胞 骨髓 细胞分化 成骨细胞 RNA环状 信号传导 综述
摘要:
骨髓间充质干细胞(bone marrow mesenchymal stem cell,BMMSC)是最早被发现的来源于骨髓的干细胞,具有向成骨细胞、软骨细胞、脂肪细胞等分化的潜能。BMMSC成骨分化是骨形成的起始环节,也是维持骨代谢平衡的关键环节。环状RNA(circular RNA,circRNA)作为一类稳定的非编码RNA,通过多样化的调控机制在BMMSC成骨分化中发挥关键作用。本文对circRNA的特点、分类及调控机制进行了概述,并从主要信号通路和核心转录因子两方面对circRNA调控BMMSC成骨分化的研究进展进行了综述。

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备注/Memo

备注/Memo:
基金项目:甘肃省科技计划项目(22JR5RA620,24JRRA902); 甘肃省中医药科研课题项目(GZKG-2024-46)
通信作者:陈杰 E-mail:2804944547@qq.com
(收稿日期:2025-08-21 本文编辑:吕宁)
更新日期/Last Update: 2026-06-20