[1]梅满,于波.微重力影响间充质干细胞向软骨细胞分化的研究进展[J].中医正骨,2019,31(01):38-40.
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微重力影响间充质干细胞向软骨细胞分化的研究进展()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期数:
2019年01期
页码:
38-40
栏目:
临床研究
出版日期:
2019-01-20

文章信息/Info

作者:
梅满1于波2
(1.山东中医药大学,山东 济南 250355; 2.山东中医药大学附属医院 山东 济南 250355)
关键词:
软骨 软骨细胞 间质干细胞 细胞分化 组织工程 失重模拟 综述
摘要:
关节软骨损伤的治疗是骨科研究的热点之一。软骨组织工程研究致力于通过构建细胞与生物材料的三维复合体,形成具有生物活性的软骨组织,在功能及形态方面完全替代缺损处的软骨,以医治大面积的软骨缺损。但在重力环境下,培养出的软骨细胞失去原有的细胞表型及电生理特性,构建出的软骨组织只能在形态和生化成分上与原缺损处软骨组织相似。而微重力环境可影响间充质干细胞的增殖和分化,有促进干细胞向软骨细胞分化的作用。本文从微重力环境的建立和优点、微重力对间充质干细胞向软骨细胞分化的影响两大方面,对近年来的研究进展进行了综述。

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备注/Memo

备注/Memo:
基金项目:山东省自然科学基金面上项目(ZR2016HM43),山东省医药卫生科技发展计划面上项目(2016WS0582),山东省济南市科技计划项目(201602183)
通讯作者:于波 E-mail:dangxiao1976@126.com
更新日期/Last Update: 2019-07-11