[1]唐中尧,李华,徐祖健.中药治疗骨质疏松症的用药规律研究[J].中医正骨,2019,31(01):20-22,25.
　TANG Zhongyao,LI Hua,XU Zujian.A study of medication rule of Traditional Chinese Medicine for treatment of osteoporosis[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2019,31(01):20-22,25.
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中药治疗骨质疏松症的用药规律研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第31卷
期数:
2019年01期
页码:
20-22,25
栏目:
临床研究
出版日期:
2019-01-20

文章信息/Info

Title:
A study of medication rule of Traditional Chinese Medicine for treatment of osteoporosis
作者:
唐中尧1; 李华2; 徐祖健2
(1.泸州市中医医院,四川 泸州 646000; 2.西南医科大学附属中医医院,四川 泸州 646000)
Author(s):
TANG Zhongyao1; LI Hua2; XU Zujian2
1.Luzhou Hospital of Traditional Chinese Medicine,Luzhou 646000,Sichuan,China 2.The TCM Hospital Affiliated to Southwest Medical University,Luzhou 646000,Sichuan,China
关键词:
骨质疏松;  中药疗法;  补益药;  活血祛瘀药
Keywords:
osteoporosis;  drug therapy(TCD);  reinforcing drugs;  blood act stasis remov drugs
摘要:
目的:分析中药治疗骨质疏松症的用药规律。方法:以“=骨质疏松症AND任意字段=中药”为检索式,应用计算机检索中国知网、维普网和万方数据3大中文数据库2007年1月1日至2017年12月31日收录的关于中药治疗骨质疏松症的文献。通过阅读文献题名、摘要、全文,按照文献的纳入和排除标准对文献进行筛选,提取文献中涉及的中药,分析用药规律。结果:初检共检索出文献1112篇,经过筛选后共纳入文献490篇,涉及中药125味。125味中药中出现频率(记录有该味药的文献数/纳入文献总数×100%)≥25%的有13味,按照出现频次排序由高至低依次为熟地黄(254次)、淫羊藿(250次)、杜仲(237次)、鹿茸(195次)、黄芪(190次)、牛膝(188次)、骨碎补(185次)、补骨脂(173次)、山萸肉(164次)、山药(160次)、茯苓(154次)、丹参(150次)、白术(145次)。13味中药涉及的药性包括温(1793次)、平(502次)、寒(150次),涉及的药味包括甘(1335次)、苦(841次)、咸(195次)、辛(173次)、酸(164次)、涩(164次)、淡(154次),脏腑归经主要归肾(2150次)、肝(1813次)、脾(822次)、肺(504次)、心(304次)经,主要功效包括补肾(1546次)、补脾(649次)、补肝(589次)、补气(444次)及活血化瘀(338次)等。结论:用于治疗骨质疏松症的常用中药依次为熟地黄、淫羊藿、杜仲、鹿茸、黄芪、牛膝、骨碎补、补骨脂、山萸肉、山药、茯苓、丹参、白术等,涉及的药性依次为温、平、寒,涉及的药味依次为甘、苦、咸、辛、酸、涩、淡,脏腑归经依次为归肾、肝、脾、肺、心经,药物主要功效依次为补肾、补脾、补肝、补气及活血化瘀等。
Abstract:
Objective:To analyze the medication rule of Traditional Chinese Medicine(TCM)for treatment of osteoporosis(OP).Methods:OP(keyword)and TCM(any field)were used as index terms to retrieve all the articles about TCM for treatment of OP included from January 1,2007 to December 31,2017 from China national knowledge internet,Vip Database and Wanfang Database through computer.The articles were screened through reading titles,abstracts and full texts according to the inclusion and exclusion criteria of the articles,and the TCMs involved in the articles were searched out,and their medication rules were analyzed.Results:One thousand one hundred and twelve articles were searched out.After screening,490 articles were included in the final analysis,including 125 TCMs.In the 125 TCMs,the occurrence frequency(ratio of the number of articles in which the TCMs were recorded to the number of all included articles)of 13 TCMs were ≥ 25%.According to high-to-low occurrence frequency,the 13 TCMs included radix rehmanniae praeparata(254 times),epimedium(250 times),eucommia ulmoides(237 times),cornu cervi pantotrichum(195 times),astragalus membranaceus(190 times),achyranthes bidentata(188 times),drynaria fortunei(185 times),fructus psoraleae(173 times),pulp of cornus(164 times),rhizoma dioscoreae(160 times),poria cocos(154 times),salvia miltiorrhiza(150 times)and atractylodes macrocephala koidz(145 times).For the 13 TCMs,the drug properties included warm(1793 times),normal(502 times)and cold(150 times); the drug flavours included sweet(1335 times),bitter(841 times),salty(195 times),pungent(173 times),sour(164 times),astringency(164 times)and bland(154 times); the Zang-Fu(viscera)meridian distributions presented mainly with kidney meridian(2150 times),liver meridian(1813 times),spleen meridian(822 times),lung meridian(504 times)and heart meridiam(304 times); and the clinical effects presented mainly with tonifying kidney(1546 times),tonifying spleen(649 times),tonifying liver(589 times),tonifying qi(444 times)and activating blood and resolving stasis(338 times).Conclusion:The common TCMs which are used for treatment of OP include radix rehmanniae praeparata,epimedium,eucommia ulmoides,cornu cervi pantotrichum,astragalus membranaceus,achyranthes bidentata,drynaria fortunei,fructus psoraleae,pulp of cornus,rhizoma dioscoreae,poria cocos,salvia miltiorrhiza and atractylodes macrocephala koidz in turn.Their drug properties present with warm,normal and cold in turn; their drug flavours present with sweet,bitter,salty,pungent,sour,astringency and bland in turn; their Zang-Fu(viscera)meridian distributions include kidney meridian,liver meridian,spleen meridian,lung meridian and heart meridiam in turn; and their clinical effects present mainly with tonifying kidney,tonifying spleen,tonifying liver,tonifying qi and activating blood and resolving stasis in turn.

参考文献/References:

[1] 史晓林,王健,王博,等.虚瘀兼顾——治疗原发性骨质疏松症的基本原则[J].中医正骨,2017,29(3):14-16.
[2] 朱国福.中药学[M].北京:清华大学出版社,2012.
[3] 袁明阳,王建伟.中医药治疗骨质疏松症的研究进展[J].世界中医药,2016,11(6):1119-1121.
[4] 柳承希,任艳玲.古代文献对骨质疏松症的认识[J].中华中医药杂志,2014,29(7):2089-2092.
[5] 陈德强,张鹏,徐展望.中药及复方治疗骨质疏松症的现代医学研究进展[J].中国误诊学杂志,2009,9(23):5561-5562.
[6] 林晓光,曾振明,潘国铨.温阳补肾汤治疗肾阳虚型老年性骨质疏松症42例临床观察[J].新中医,2013,45(12):88-90.
[7] 金芳梅,王海东.补肾温阳法防治骨质疏松症探讨[J].中医研究,2011,24(8):6-8.
[8] 欧莉,卫培峰,苗彦霞.黄芪配伍熟地对去势大鼠骨质疏松的治疗作用[J].中国药理学与毒理学杂志,2013,27(3):363-366.
[9] XIE F,WU CF,LAI WP,et al.The osteoprotective effect of Herba epimedii(HEP)extract in vivo and in vitro[J].Evid Based Complement Alternat Med,2005,2(3):353-361.
[10] 李三华,刘坤祥,莫宁萍,等.RT-PCR法检测杜仲总黄酮对大鼠成骨细胞骨钙素表达的影响[J].遵义医学院学报,2011,34(3):223-225.
[11] 蔡玉霞,张剑宇.补骨脂水煎剂对去卵巢骨质疏松大鼠骨代谢的影响[J].中国组织工程研究与临床康复,2009,13(2):268-271.
[12] LI YJ,KIM TH,KWAK HB,et al.Chloroform extract of deer antler inhibits osteoclast differentiation and bone resorption[J].J Ethnopharmacol,2007,113(2):191-198.
[13] 李平,李晶,王惠明.山茱萸总苷对去势大鼠骨代谢和骨密度影响的实验研究[J].天津中医药,2007,24(4):315-317.
[14] 邢燕,毕宏焱,张倩楠,等.骨质疏松常用中成药介绍[J].中国骨质疏松杂志,2013,19(1):83-85.
[15] 王日生.活血化瘀中药药理作用探析[J].亚太传统医药,2014,10(4):74-75.
[16] 任心慈,徐先祥,许杜娟,等.牛膝总皂苷防治实验性骨质疏松作用研究[J].安徽医药,2010,14(10):1133-1135.
[17] 上官文姬,李鹤,汤璐敏.骨碎补总黄酮对大鼠成骨细胞VEGF和FGF-2表达的影响[J].辽宁中医药大学学报,2014,16(8):38-41.
[18] 周延萌,刘玉波,高允生,等.丹参酮对维甲酸致小鼠骨质疏松的防治作用[J].中国中药杂志,2010,35(21):2923-2926.

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更新日期/Last Update: 2019-07-11