[1]王洁,王萧枫.淫羊藿总黄酮的抗骨质疏松作用及其对调控成骨细胞分化及骨形成关键信号通路的影响[J].中医正骨,2017,29(01):45-48.
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淫羊藿总黄酮的抗骨质疏松作用及其对调控成骨细胞分化及骨形成关键信号通路的影响()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第29卷
期数:
2017年01期
页码:
45-48
栏目:
综述
出版日期:
2017-01-20

文章信息/Info

作者:
王洁1王萧枫2
1.安徽中医药大学,安徽 合肥 230012;
2.浙江省温州市中西医结合医院,浙江 温州 325000
关键词:
淫羊藿 骨质疏松 成骨细胞 细胞分化 骨生成 信号传导 Wnt信号通路 综述
摘要:
淫羊藿总黄酮(total flavonoids of epimedium,TFE)的抗骨质疏松作用已被临床研究证实,但其具体作用机制尚不完全清楚,可能通过激活与成骨细胞相关的信号通路发挥作用。调控成骨细胞分化及骨形成的关键信号通路主要包括骨形态发生蛋白(bone morphogenetic protein,BMP)/Smads信号通路、Wnt/β-连环蛋白信号通路、Notch信号通路、Hedgehog信号通路及成纤维细胞生长因子(fibroblast growth factor,FGF)信号通路等。本文就TFE的抗骨质疏松作用和TFE对调控成骨细胞分化及骨形成的关键信号通路的影响进行了综述。

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备注/Memo

备注/Memo:

通讯作者:王萧枫 E-mail:wzwxfs@139.com
更新日期/Last Update: 2017-01-20