[1]李冠慧,李灿东,李西海,等.雌激素调控绝经后骨质疏松症骨吸收-骨形成 耦联失衡的机制[J].中医正骨,2016,28(02):36-40.
点击复制

雌激素调控绝经后骨质疏松症骨吸收-骨形成 耦联失衡的机制()
分享到:

《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第28卷
期数:
2016年02期
页码:
36-40
栏目:
学术探讨
出版日期:
2016-02-20

文章信息/Info

作者:
李冠慧李灿东李西海梁文娜
福建中医药大学,福建 福州 350122
关键词:
雌激素类 骨质疏松绝经后 骨生成 骨质吸收 骨代谢
摘要:
绝经后骨质疏松症指妇女绝经后卵巢功能衰退、内分泌失调,引起雌激素水平下降,继发甲状旁腺功能亢进,降钙素分泌 不足,从而导致骨吸收大于骨形成的代谢性疾病。骨重建过程的主要功能细胞是破骨细胞和成骨细胞,二者经由多种信号通路影 响着对方的分化、聚集和功能活动。雌激素作为免疫细胞和骨细胞的共同交叉机制,通过经典激素受体途径,调节T细胞的活化 和免疫因子的产生表达,影响成骨细胞、破骨细胞、免疫细胞的活性和功能; 通过雌激素受体途径,调节破骨细胞与成骨细胞的 增殖、分化、凋亡,参与骨形成与骨吸收的调控。雌激素对骨重建方向的影响,既有正性调节作用,又有负性调节作用。因此,雌 激素通过直接调节机制和旁分泌机制,影响成骨细胞、破骨细胞的活性和功能,在绝经后骨质疏松症骨吸收-骨形成耦联失衡的 病理过程中发挥着重要的调控作用。本文从骨形成-骨吸收与骨量的关系、雌激素调控骨形成-骨吸收耦联的机制以及雌二醇调 控骨代谢的作用机制3个方面进行了阐述。

参考文献/References:

[1] 梁文娜,李西海,李灿东,等.骨免疫与绝经后骨质疏松妇女骨重建失衡[J].国际骨科学杂志,2012,33(2):103-105.
[2] Somjen D,Katzburg S,Sharon O,et al.The effects of estrogen receptors α- and β-specific agonists and antagonists on cell proliferation and energy metabolism in human bone cell line[J].J Cell Biochem,2011,112 (2):625-632.
[3] 粱文娜,叶蕻芝,廖凌虹,等.Ⅰ型胶原蛋白对骨矿化机制的影响[J].中国老年学杂志,2012,32(17):3840-3842.
[4] Li Y,Liang W,Li X,et al.Effect of serum from postmenopausal women with osteoporosis exhibiting the Kidney-Yang deficiency pattern on bone formation in an hFOB 1.19 human osteoblastic cell line[J].Exp Ther Med,2015,10(3):1089-1095.
[5] Jabbar S,Drury J,Fordham J,et al.Osteoprotegerin,RANKL and bone turnover in postmenopausal osteoporosis [J].Osteoporosis International,2009,20(4):S271.
[6] Chen X,Talati M,Fessel JP,et al.Estrogen metabolite 16α-Hydroxyestrone exacerbates bone morphogenetic protein receptor typeII-associated pulmonary arterial hypertension through microRNA-29-mediated modulation of cellular metabolism[J].Circulation,2016,133(1):82-97.
[7] Liang W,Li X,Li Y,et al.Tongue coating microbiome regulates the changes in tongue texture and coating in patients with post-menopausal osteoporosis of Gan-shen deficiency syndrome type[J].Int J Mol Med,2013,32 (5):1069-1076.
[8] Sugiya N,Nakashima A,Takasugi N,et al.Endogenous estrogen May prevent bone loss in postmenopausal hemodialysis patients throughout Life[J].Osteoporos Int,2011,22(5):1573-1579.
[9] Zheng XK,Zhang X,Wang XL,et al.Effect of estrogen-like effective part of selaginella tarmariscina on bone metabolism[J].Zhong Yao Cai,2014,37(10):1825-1829.
[10] Chen Z,Wang O,Nie M,et al.Aromatase deficiency in a Chinese adult man caused by novel compound heterozygous CYP19A1 mutations: effects of estrogen replacement therapy on the bone, lipid, liver and glucose metabolism[J].Mol Cell Endocrinol,2015,399(9):32-42.
[11] 宋才渊,彭冰,沈佳怡,等.破骨细胞分化调节机制的研究进展[J].中国骨伤,2015,28(6):580-584.
[12] 俞索静,肖鲁伟,吴承亮,等.破骨细胞血系起源的活细胞成像观察[J].中国骨伤,2012,25(4):317-323. 中医正骨2016年2月第28卷第2期 J Trad Chin Orthop Trauma,2016,Vol.28,No.2(总119) (总120)中医正骨2016年2月第28卷第2期 J Trad Chin Orthop Trauma,2016,Vol.28,No.2
[13] Brown JP,Dempster DW,Ding B,et al.Bone remodeling in postmenopausal women who discontinued denosumab treatment: off-treatment biopsy study[J].J Bone Miner Res,2011,26(11):2737-2744.
[14] Rachner TD,Rauner M.RANKL/OPG in breast cancer - extending its territory to BRCA mutation carriers [J].EBioMedicine,2015,2(10):1270-1271.
[15] Smith G,Stassen L,Flint S.Treating osteoporosis[J].Irish Medical Journal,2009,102(3):171-172.
[16] 黄立莉,洪文,王立源,等.绝经后骨质疏松症的临床治疗进展[J].中国医药导报,2011,8(18):7-10.
[17] Walsh MC,Kim N,Kadono Y,et al.Osteoimmunology:interplay between the immune system and bone metabolism [J].Annu Rev Immunol,2006,24(1):33-63.
[18] 孙哲,林志勇,白广亮,等.甲状旁腺激素与雌激素对去势雌性大鼠牙槽骨代谢的影响[J].华西口腔医学杂志,2014,32 (2):134-137.
[19] Liang W,Lin M,Li X,et al.Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line[J].Int J Mol Med,2012,30(4):889-895.
[20] Bona H,Aroso M,Rinn C,et al.Analysis of low abundance membrane-associated proteins[J].Proteome Res,2010,9(10):4927-4939.
[21] Xiang Q,Lin G,Fu X,et al.The role of peroxisome proliferator-activated receptor-gamma and estrogen receptors in genistein-induced regulation of vascular tone in female rat aortas[J].Pharmacology,2010,86 (2):117-124.
[22] Sang C,Zhang Y,Chen F,et al.Tumor necrosis factor alpha suppresses osteogenic differentiation of MSCs by inhibiting semaphorin 3B via Wnt/β-catenin signaling in estrogen-deficiency induced osteoporosis [J].Bone,2015,84(6):78-87.
[23] 粱文娜,李灿东,李西海,等.绝经后骨质疏松症中医证素分布的临床研究[J].福建中医药大学学报,2012,22(2):11-13.
[24] 梁文娜,李亚婵,李西海,等.绝经后骨质疏松症肾阳虚证证素变化与熵变的内在关系[J].中华中医药杂志,2014,29 (6):1791-1793.
[25] Ma F,Gong F,Lv J,et al.Effects of a7nAChR agonist on the tissue estrogen receptor expression of castrated rats[J].Int J Clin Exp Pathol,2015,8(10):13421-13425.
[26] Liao L,Su X,Yang X,et al.TNF-α inhibits FoxO1 by up-regulating MiR-705 to aggravate oxidative damage in bone Marrow-Derived mesenchymal stem cells during osteoporosis[J].Stem Cells,2015,5(10):1002-1004.
[27] Bertonazzi A,Nelson B,Salvador J,et al.The smallest available estradiol transdermal patch:a new treatment option for the prevention of postmenopausal osteoporosis[J].Womens Health(Lond Engl),2015,11(6):815-824.
[28] Tseng SH,Chen LG,Lai YJ,et al.Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers[J].Animal Science Journal,2015,10(6):1111-1120.
[29] Kovacic N,Grcevic D,Katavic V,et al.Fas receptor is required for estrogen deficiency-induced bone loss in mice[J].Lab Invest,2010,90(3):402-413.
[30] Syed FA,Fraser DG,Monroe DG,et al.Distinct effects of loss of classical estrogen receptor signaling versus complete deletion of estrogen receptor alpha on bone[J].Bone,2011,49(2):208-216.
[31] Widschwendter M,Burnell M,Fraser L,et al.Osteoprotegerin(OPG),the endogenous inhibitor of receptor activator of NF-κB ligand(RANKL),is dysregulated in BRCA mutation carriers[J].EBioMedicine,2015,2(10):1331- 1339.
[32] Cervellati C,Romani A,Cremonini E,et al.Higher urinary levels of 8-Hydroxy-2'-deoxyguanosine are associated with a worse RANKL/OPG ratio in postmenopausal women with osteopenia[J].Oxid Med Cell Longev,2016, (9):6038.
[33] 薛昊罡,冷冰,马恩元,等.雌激素水平与绝经女性并发骨质疏松症的相关性研究[J].中国妇幼保健,2011,26(26):4106- 4108.
[34] Zheng X,Lee SK,Chun OK.Soy isoflavones and osteoporotic bone loss:a review with an emphasis on modulation of bone remodeling[J].J Med Food,2016,19(1):1-14.
[35] 李雪峰,李冠武,常时新,等.MRI水/脂分离技术评价雌激素对骨质疏松骨髓脂肪的作用[J].实用放射学杂志,2015,31 (3):480-483.
[36] Gobek K,Ostrowska Z,Ziora K,et al.Association between omentin-1,bone metabolism markers,and cytokines of the RANKL/RANK/OPG system in girls with anorexia nervosa[J].Endokrynol Pol,2015,66(6):514-520.
[37] 马培奇.绝经后妇女骨质疏松症防治用选择性雌激素受体调节剂研究进展[J].中国制药信息,2015,31(7):10-13.
[38] 李联祥,王黎光,申育华,等.正常及异常组织中雌激素α及β受体的表达[J].中国组织工程研究与临床康复,2010,14 (50):9442-9446.
[39] 王啸,刘禄林,沈光思,等.雌激素下降合并铁蓄积对骨组织骨量影响的实验研究[J].中华骨科杂志,2015,35(10):1011- 1016.
[40] Yoldemir T,Erenus M,Durmusoglu F.The impact of serum FSH and estradiol on postmenopausal osteoporosis related to time since menopause[J].Gynecol Endocrinol,2012,28(11):884-888.
[41] 王亚春,孙绍骞,王锐,等.雌激素和骨标志物与绝经后妇女骨质疏松的关系[J].中国妇幼保健,2015,30(27):4675-4676.
[42] Trombelli L,Penolazzi L,Torreggiani E,et al.Effect of hydroxyapatite-based biomaterials on human osteoblast phenotype[J].Minerva Stomatol,2010,59(3):103-115.
[43] Saha H,Mukherjee B,Bindhani B,et al.Changes in RANKL and osteoprotegerin expression after chronic exposure to indoor air pollution as a result of cooking with biomass fuel[J].J Appl Toxicol,2015,22(2):297- 301.
[44] Bougioukli S,Jain A,Sugiyama O,et al.Combination therapy with BMP-2 and a systemic RANKL inhibitor enhances bone healing in a mouse critical-sized femoral defect[J].Bone,2015,84(2):93-103.
[45] Yu XJ,Xiao CJ,Du YM,et al.Effect of hypoxia on the expression of RANKL/OPG in human periodontal ligament cells in vitro[J].Int J Clin Exp Pathol,2015,8(10):12929-12935.

相似文献/References:

[1]刘磊,万春友,全先辉,等.锁定钢板内固定结合肱骨头植骨重建治疗 肱骨近端Neer三、四部分骨折[J].中医正骨,2015,27(10):52.
[2]徐伟锋,叶健,吴连国.强骨饮对骨质疏松性股骨颈骨折患者全髋关节置换术后 血清骨代谢生化指标和骨密度的影响[J].中医正骨,2015,27(02):12.
 XU Weifeng,YE Jian,WU Lianguo.Effect of Qianggu Yin(强骨饮,QGY)on serum bone metabolism indexes and bone density after total hip arthroplasty in patients with osteoporotic femoral neck fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(02):12.
[3]龚江浩.股骨近端防旋髓内钉联合抗骨质疏松药物治疗 不稳定型老年股骨转子间骨折的临床观察[J].中医正骨,2015,27(04):29.
 GONG Jianghao.A combination therapy of proximal femoral nail antirotation and anti-osteoporotic drugs for the treatment of unstable femoral intertrochanteric fractures in the aged[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2015,27(02):29.
[4]费国芳,费红良,王金法.两种内固定方法治疗老年不稳定性股骨转子间骨折的对比研究[J].中医正骨,2016,28(05):9.
 FEI Guofang,FEI Hongliang,WANG Jinfa.Comparison of two kinds of internal fixation for treatment of unstable femoral intertrochanteric fractures in the aged[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(02):9.
[5]陈思凯,邢金明.骨水泥强化椎弓根螺钉内固定治疗老年胸腰椎压缩性骨折[J].中医正骨,2016,28(05):35.
[6]孙鹏,谭磊,阎乾,等.人工肱骨头置换术治疗老年肱骨近端Neer三、四部分骨折[J].中医正骨,2016,28(05):43.
[7]王博,吴鹏,史晓林.强骨饮对去卵巢骨质疏松大鼠骨显微结构的影响[J].中医正骨,2016,28(07):6.
 WANG Bo,WU Peng,SHI Xiaolin.A retrospective trial of postural reduction combined with percutaneous vertebroplasty versus percutaneous kyphoplasty for treatment of osteoporotic vertebral compression fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(02):6.
[8]冯建军,邹浩,朱海燕,等.槲皮素对去卵巢大鼠血清骨钙素和股骨Ⅰ型胶原蛋白水平的影响[J].中医正骨,2016,28(07):10.
 FENG Jianjun,ZOU Hao,ZHU Haiyan,et al.Leverage bone grafting and pedicle screw internal fixation through posterior approach for treatment of thoracolumbar fractures[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(02):10.
[9]王吉利,万雷,张志海,等.抑制Dickkopf-1和Sclerostin表达对人成骨肉瘤细胞MG63骨代谢调节相关蛋白表达水平的影响[J].中医正骨,2016,28(09):13.
 WANG Jili,WAN Lei,ZHANG Zhihai,et al.Effect of suppression of Dickkopf-1 and Sclerostin expression on bone metabolism regulatory protein expression levels in human osteosarcoma MG63 cells[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2016,28(02):13.
[10]张国文.肱骨近端锁定接骨板内固定治疗肱骨近端骨折[J].中医正骨,2016,28(08):50.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(81202645); 福建省自然科学基金项目(2015J01339); 福建省卫生系统中青年骨干人才培养 项目(2015-ZQN-JC-32); 2015年度福建省高等学校新世纪优秀人才支持计划
通讯作者:梁文娜 E-mail:liangwenna1979@163.com
更新日期/Last Update: 2016-04-30