[1]宋永枝,陈双玲.唑来膦酸静脉滴注联合鲑降钙素肌肉注射治疗 骨质疏松性长骨骨折[J].中医正骨,2016,28(01):70-71.
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唑来膦酸静脉滴注联合鲑降钙素肌肉注射治疗 骨质疏松性长骨骨折()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第28卷
期数:
2016年01期
页码:
70-71
栏目:
临床报道
出版日期:
2016-01-20

文章信息/Info

作者:
宋永枝陈双玲
河南科技大学第二附属医院,河南 洛阳 471000
关键词:
骨质疏松性骨折 唑来膦酸 鲑降钙素 骨密度
摘要:
目的:观察唑来膦酸静脉滴注联合鲑降钙素肌肉注射治疗骨质疏松性长骨骨折的临床疗效和安全性。方法:2010年3月至2012年3月,采用唑来膦酸静脉滴注联合鲑降钙素肌肉注射治疗骨质疏松性长骨骨折患者100例,男44例、女56例。年龄63~93岁,中位数73岁。观察患者骨密度改善、骨折愈合及并发症发生情况。结果:治疗3年后,股骨颈骨密度高于治疗前[(0.856±0.205),(0.714±0.197),t=4.012,P=0.021],L1~L4骨密度高于治疗前[(0.774±01.5),(0.624±0.167),t=4.356,P=0.001]。所有骨折均愈合。均未出现骨折延迟愈合或不愈合等并发症。结论:采用唑来膦酸静脉滴注联合鲑降钙素肌肉注射治疗骨质疏松性长骨骨折,能够明显提高骨密度,骨折愈合好,并发症少,值得临床推广应用。

参考文献/References:

[1] 张鑫,刘波,刘辉,等.骨质疏松症的诊断标准及其相关影响因素[J].中医正骨,2012,24(3):33-35.
[2] Godoy Monzón D,Iserson KV,Jauregui J,et al.Total hip arthroplasty for hip fractures:5-year follow-up of functional outcomes in the oldest Independent old and very old patients[J].Geriatr Orthop Surg Rehabil,2014,5(1):3-8.
[3] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊治指南[J].中国骨质疏松杂志,2011,8(3):2.
[4] 宣淼,杨军,李颖,等.唑来膦酸与替勃龙对绝经后骨质疏松症骨密度、骨代谢指标及骨折影响的临床研究[J].中华内分泌代谢杂志,2013,29(6):504-508.
[5] Chao M,Hua Q,Yingfeng Z,et al.Study on the role of zoledronic acid in treatment of postmenopausal osteoporosis women[J].Pak J Med Sci,2013,29(6):1381-1384.
[6] Khajuria DK,Razdan R,Mahapatra DR.Zoledronic acid in combination with alfacalcidol has additive effects on trabecular microarchitecture and mechanical properties in osteopenic ovariectomized rats[J].J Orthop Sci,2014,19(4):646-656.
[7] 黄建武,黄建华,林爱菊.补肾健骨汤合阿伦磷酸钠对绝经后骨质疏松症患者骨密度和性激素水平的影响[J].中医正骨,2013,25(8):30-31.
[8] 林华,徐天舒,范璐,等.5mg唑来膦酸治疗绝经后骨质疏松及其骨折[J].中华创伤骨科杂志,2012,14(1):31-35.
[9] Li CY,Mori S,Li JL,et al.Long-term effect of incadronate disodium(YM-175)on fracture healing of femoral shaft in growing rats[J].J Bone Mineral Research,2001,16(3):429-436.
[10] Sahana H,Khajuria DK,Razdan R,et al.Improvement in bone properties by novel nanoparticle based formulation in a rat model of osteporosis[J].J Biomed Nanotechnol,2013,9(2):193-201.
[11] 聂海,彭超,郝杰,等.唑来膦酸预防绝经妇女骨质疏松性骨折的meta分析[J].第二军医大学学报,2011,32(9):985-990.
[12] Briot K,Cortet B,Thomas T,et al.2012 update of French guidelines for the pharmacological treatment of postmenopausal osteoporosis[J].Joint Bone Spine,2012,79(3):304-313.
[13] 郭艾,罗先正,任素梅,等.股骨假体周围骨密度定量测定[J].中国骨质疏松杂志,1999,5(3):28.
[14] Shen Y,Li XM,Ding YR,et al.Stro-1-positive BMSCs predict postoperative periprosthetic bone mineral density outcomes in uncemented total hip arthroplasty patients[J].Med Sci Monit,2014,20:361-367.
[15] 王博,李玉雄.抗骨疏胶囊治疗原发性骨质疏松症的临床研究[J].中医正骨,2010,22(5):21-23.

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更新日期/Last Update: 2016-02-29