[1]高广凌,黄相杰,姜红江,等.接骨药丸防治人工股骨头置换术后 假体周围骨质疏松的疗效观察[J].中医正骨,2013,25(09):19-21.
　Gao Guangling*,Huang Xiangjie,Jiang Hongjiang,et al.Evaluation of the preventative effect of JIEGUYAO pill on periprosthetic osteoporosis after hip hemiarthroplasty[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2013,25(09):19-21.
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接骨药丸防治人工股骨头置换术后 假体周围骨质疏松的疗效观察()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第25卷
期数:
2013年09期
页码:
19-21
栏目:
临床研究
出版日期:
2013-09-30

文章信息/Info

Title:
Evaluation of the preventative effect of JIEGUYAO pill on periprosthetic osteoporosis after hip hemiarthroplasty
作者:
高广凌; 黄相杰; 姜红江; 焦明航; 王亮
山东省文登整骨医院,山东 文登 264400
Author(s):
Gao Guangling*; Huang Xiangjie; Jiang Hongjiang; Jiao Minghang; Wang Liang.*
The Wendeng Osteopath Hospital,Wendeng 264400, Shandong,China
关键词:
骨质疏松 接骨药丸 关节成形术; 置换; 髋 治疗; 临床研究性
Keywords:
Osteoporosis;  JIEGUYAO pill;  Arthroplasty; replacement; hip;  Therapies; investigational
摘要:
目的:观察接骨药丸防治人工股骨头置换术后假体周围骨质疏松的临床疗效。方法:将72例需行人工股骨头置换术的股骨 颈骨折患者随机分为2组,每组36例。人工股骨头置换术后,治疗组患者口服接骨药丸治疗,连续服用2个月; 对照组患者口服活性 维生素D治疗,连续服用2个月。分别于服药前和服药2个月后测定2组患者的股骨骨密度、血清碱性磷酸酶含量及疼痛程度分级, 并根据以上3个指标制定疗效评定标准,评定患者的临床综合疗效。结果:①骨密度。治疗前2组患者骨密度比较,差异无统计学意 义(t=-0.079,P=0.937); 治疗后2组患者骨密度均增高[(0.449±0.060)g·cm-2,(0.544±0.072) g·cm-2,t=8.638,P=0.000;(0.450±0.058)g·cm-2,(0.507±0.069)g·cm- 2,t=6.107,P=0.000],治疗组增高更明显[(0.095±0.066)g·cm-2,(0.057±0.056)g·cm- 2,t=2.654,P=0.038]。②血清碱性磷酸酶含量。治疗前2组患者血清碱性磷酸酶含量比较,差异无统计学意义(t=- 0.135,P=0.893); 治疗后2组患者血清碱性磷酸酶含量均增高[(8.080±0.498)μg·L-1,(9.090±0.452) μg·L-1,t=9.770,P=0.000;(8.096±0.500)μg·L-1,(8.644±0.408)μg·L- 1,t=6.495,P=0.000],治疗组增高更明显[(1.010±0.618)μg·L-1,(0.549±0.507)μg·L- 1,t=3.463,P=0.001]。③临床综合疗效。治疗组显效12例、有效22例、无效2例,对照组显效6例、有效21例、无效9例,治 疗组临床综合疗效优于对照组( 治疗组=31.33, 对照组=41.67,Z=-2.390,P=0.017)。结论:接骨药丸可明显提高股骨头置换术后 患者股骨骨密度和血清碱性磷酸酶含量,防治假体周围骨质疏松的疗效优于活性维生素D。
Abstract:
Objective:To observe the curative effect of JIEGUYAO pill in the prevention of periprosthetic osteoporosis after hip hemiarthroplasty.Methods:Seventy-two patients with femoral neck fracture who needed hip hemiarthroplasty were randomly divided into treatment group and control group,36 cases in each group.After the operation,the patients in treatment group were administered with JIEGUYAO pills for 2 months,while the others in control group were administered with activated vitamin D for 2 months.Femoral bone mineral density (BMD),alkaline phosphatase(ALP)contents and pain degrees were determined before and after the treatment.Based on the determination results,the total clinical curative effects were evaluated according to the self-designed evaluation standard.Results:There was no statistical difference in the femoral BMD between the 2 groups before the treatment(t=-0.079,P=0.937); while the femoral BMD increased in both of the 2 groups after the treatment (0.449+/-0.060 vs 0.544+/-0.072 g/cm(2),t=8.638,P=0.000; 0.450+/-0.058 vs 0.507+/-0.069 g/cm (2),t=6.107,P=0.000),and the femoral BMD increased more significantly in the treatment group(0.095+/-0.066 vs 0.057+/-0.056 g/cm(2),t=2.654,P=0.038).There was no statistical difference in the ALP contents between the 2 groups before the treatment(t=-0.135,P=0.893); while the ALP contents increased in both of the 2 groups after the treatment(8.080+/-0.498 vs 9.090+/-0.452 μg/L,t=9.770,P=0.000; 8.096+/-0.500 vs 8.644+/-0.408 μg/L,t=6.495,P=0.000),and the ALP contents increased more significantly in the treatment group(1.010+/-0.618 vs 0.549+/-0.507 μg/L,t=3.463,P=0.001).Twelve patients got a good result,22 fair,and 2 poor in the treatment group; while 6 patients got a good result,21 fair,and 9 poor in the control group.The treatment group surpassed the control group in the total curative effect((-overR)treatment group=31.33,(-overR)control group=41.67,Z=-2.390,P=0.017).Conclusion:The JIEGUYAO pill can obviously increase the femoral BMD and ALP contents in the patients after hip hemiarthroplasty,and it has better preventative effects on periprosthetic osteoporosis compared with activated vitamin D.

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备注/Memo

备注/Memo:
2013-03-12收稿 2013-05-07修回
基金项目:山东省科技发展计划项目(2010GFS10286)
更新日期/Last Update: 2013-09-30