[1]张建,李嘉程,王辉,等.基于肠-骨轴理论探讨肠道菌群对股骨头坏死的作用机制[J].中医正骨,2025,37(04):77-80.
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基于肠-骨轴理论探讨肠道菌群对股骨头坏死的作用机制()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第37卷
期数:
2025年04期
页码:
77-80
栏目:
学术探讨
出版日期:
2025-04-20

文章信息/Info

作者:
张建1李嘉程2王辉2贾海峰1李翰政1李学澳1许波2
1.山东中医药大学第一临床医学院,山东 济南 250014; 2.山东中医药大学附属医院,山东 济南 250014
关键词:
胃肠道微生物群 股骨头坏死 肠-骨轴 骨代谢
摘要:
肠道菌群作为人体内最复杂、种群数量最多的微生物群,对人体的代谢平衡、免疫调节等具有多维度、动态性的作用。肠-骨轴是指肠道微生物群与骨骼之间的双向调控网络,通过代谢物、免疫系统和内分泌系统等途径,肠道微生物能够直接影响骨代谢或间接调节骨稳态。股骨头坏死(osteonecrosis of femoral head,ONFH)的治疗是临床难题,基于肠-骨轴理论探讨肠道菌群对ONFH的作用机制,可为ONFH的防治提供新的思路。本文阐述了肠-骨轴理论及肠道菌群影响骨代谢的机制,探讨了肠道菌群通过调节骨代谢、脂质代谢、微循环和氧化应激等途径影响ONFH的机制,为通过肠道菌群防治ONFH提供了理论依据。

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备注/Memo

备注/Memo:
基金项目:山东省自然科学基金项目(ZR2022LZY003)
通讯作者:许波 E-mail:szyxubo@163.com
更新日期/Last Update: 1900-01-01