[1]罗月中,李芸,李勇,等.补肾健骨法预防肾病综合征患者 激素性股骨头坏死临床研究[J].中医正骨,2011,23(01):3-6.
 LUO Yue-zhong*,LI Yun,LI Yong,et al.Preventive effect of Reinforcing Kindney therapy on steroid-induced femoral head necrosis in patients with nephritic syndrome[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2011,23(01):3-6.
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补肾健骨法预防肾病综合征患者 激素性股骨头坏死临床研究()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第23卷
期数:
2011年01期
页码:
3-6
栏目:
临床研究
出版日期:
2011-01-30

文章信息/Info

Title:
Preventive effect of Reinforcing Kindney therapy on steroid-induced femoral head necrosis in patients with nephritic syndrome
作者:
罗月中1李芸2李勇1何伟1
1.广州中医药大学第一附属医院,广东 广州 510405;
2.广东省深圳市中医院,广东 深圳 518020
Author(s):
LUO Yue-zhong*LI YunLI Yonget al.*
No.1 Affiliated Hospital of Guangdong University of Chinese Medicine,Guangzhou 518020,Guangdong,China
关键词:
肾病综合征 股骨头坏死 糖皮质激素类 补肾
Keywords:
Nephrotic Syndrome Femur Head Necrosis Glucocorticoids Reinforcing Kindney
摘要:
目的:探讨补肾健骨中药预防肾病综合征患者激素性股骨头坏死的效果。方法:将符合标准的60例肾病综合征患者随机分 为2组,每组30例。治疗组口服补肾健骨中药胶囊,对照组给予安慰剂。①在给药期间出现明显股骨头坏死症状者行MRI检查,6个 月给药期内未出现明显股骨头坏死症状者在给药结束后行MRI检查评估股骨头坏死情况。②评估给药前后患者肾虚证候总积分。 ③在实验开始后3个月、6个月时分别行血分析、尿分析、肝肾功能和心电图以评估药物安全性。结果:①6个月内治疗组无股骨 头坏死发生,对照组3例6髋发生坏死,差异有统计学意义(P=0.027)。②给药6个月后治疗组和对照组肾虚证候积分均较治疗前降 低(t=15.989,P=0.000; t=14.198,P=0.000),且治疗组证候积分降低值大于对照组(t=9.709,P=0.000)。③两组均未发生不良反 应。结论:补肾健骨法对预防肾病综合征患者激素性股骨头坏死有一定的效果,值得多中心大样本的临床研究证实其疗效以及深 入的基础研究探索其机理。
Abstract:
Objective:To investigate the preventive effect of Reinforcing Kidney therapy on steroid-induced femoral head necrosis in patients with nephritic syndrome.Methods:60 cases met the criterion of nephritic syndrome were randomly divided into 2 groups,30 cases in each group.Patients in treatment group received capsule full of reinforcing kindney herb for 6 months,while patients in control group received placebo.①When significant symptom of femoral head necrosis appeared or at the end of treatment,all patients underwent bilateral hip MRI to screen for necrosis of the femoral head.②The kidney-deficiency scores were evaluated and documented before and after the treatment.③Blood,urine,liver and kidney function,and EKG were analyzed at the third months and sixth months of treatment for drug safety evaluation.Results:①Within the 6 months,necrosis occurred in bilateral femoral heads of three patients in control group and none femoral head necrosis occurred in treatment group on MRI.There was significant difference between the 2 groups(P=0.027).②The kidney- deficiency scores decreased in both groups after 6-month treatment(t=15.989,P=0.000; t=14.198,P=0.000)and the scores of treatment group decrease more(t=9.709,P=0.000).③There were no adverse effects documented.Conclusion:Reinforcing Kindney therapy may has some preventive effect on femoral head necrosis in patients sustained nephritic syndrome with application of steroid.Multi-center clinical trial and basic research are needed for further study.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(30772863)
通讯作者:罗月中 Email:luoyuezhong@126.com
更新日期/Last Update: 2011-01-30