[1]顾勇,赵艳明,童培建,等.基于数据挖掘法探讨中药复方治疗股骨头坏死的组方规律[J].中医正骨,2021,33(06):49-53.
 GU Yong,ZHAO Yanming,TONG Peijian,et al.A study of medication rule of Traditional Chinese Medicine compounds for treatment of osteonecrosis of femoral head based on data mining approach[J].The Journal of Traditional Chinese Orthopedics and Traumatology,2021,33(06):49-53.
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基于数据挖掘法探讨中药复方治疗股骨头坏死的组方规律()
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《中医正骨》[ISSN:1001-6015/CN:41-1162/R]

卷:
第33卷
期数:
2021年06期
页码:
49-53
栏目:
数据库研究
出版日期:
2021-06-20

文章信息/Info

Title:
A study of medication rule of Traditional Chinese Medicine compounds for treatment of osteonecrosis of femoral head based on data mining approach
作者:
顾勇1赵艳明1童培建2肖鲁伟2
1.浙江中医药大学第一临床医学院,浙江 杭州 310053; 2.浙江省中医院,浙江 杭州 310006
Author(s):
GU Yong1ZHAO Yanming1TONG Peijian2XIAO Luwei2
1.The First Clinical Medical College of Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China 2.Zhejiang Provincial Hospital of Traditional Chinese Medicine,Hangzhou 310006,Zhejiang,China
关键词:
股骨头坏死 中药疗法 组方原则 方剂分析计算机辅助 数据挖掘 聚类分析 专利
Keywords:
femur head necrosis drug therapy(TCD) formula composing principles formula anal comput assist data mining cluster analysis patents
摘要:
目的:探讨中药复方治疗股骨头坏死的组方规律。方法:检索2000年11月1日至2020年10月31日,国家知识产权局中国专利公布公告网站(http://epub.cnipa.gov.cn)发布的含有中药复方的治疗股骨头坏死(osteonecrosis of femoral head,ONFH)的专利。筛选检索到的专利项目,将专利中中药复方组成药物的名称规范后录入Microsoft Excel 2010软件和中医传承辅助平台(V2.5),建立数据库。对复方中中药的性味归经及出现频次进行统计,分析组方规律,并根据分析结果组合新方。结果:共纳入184项专利,包含184个中药复方,共有中药640味。常用中药有172味(出现频次≥3次),药性主要为温、平,药味主要为甘、苦、辛,归经多归于肝、肾、脾经。出现频次较高的药对由高至低依次为没药-乳香、骨碎补-当归、熟地黄-当归等,出现频次较高的角药由高至低依次为没药-乳香-当归、没药-乳香-骨碎补、红花-没药-乳香等。分析得到药物组合的13条关联规则,置信度最高的关联规则是乳香-骨碎补→没药; 关联度最高的药对是乳香-牛膝; 得到红参-麝香-猪胆粉、党参-淫羊藿-鸡血藤、白术-川芎-茯苓等23条3味药物的核心组合; 提取了8组新方药物核心组合,组合了4个新方。结论:中药复方治疗ONFH,多采用药性温、平,药味甘、苦、辛,归肝、肾、脾经的中药; 以调补肝肾、活血化瘀、益气健脾药为主。
Abstract:
Objective:To explore the medication rule of Traditional Chinese Medicine(TCM)compounds for treatment of osteonecrosis of femoral head(ONFH).Methods:All authorized patents about TCM compounds for treatment of ONFH included from November 1,2000 to October 31,2020 were retrieved from the website(http://epub.cnipa.gov.cn)of China Patent Announcement of China National Intellectual Property Administration through computer.The obtained patents were screened,and the TCM compounds involved in the patents were extracted and their names were standardized and input into Microsoft Excel 2010 software and TCM inheritance support system(TCMISS)software(V2.5)to build the database.The statistics on property,flavour,meridian distribution and usage frequency of the TCM in compounds were conducted for analyzing medication rules and synthesizing new prescriptions.Results:One hundred and eighty-four patents were inculded in the final study,involving 184 TCM compounds and 640 TCMs,among which 172 ones were commonly used(occurrence frequency≥3 times),and they exhibited the drug property mainly as warm and normal,the drug flavours mainly as sweet,bitter and pungent,and the meridian distributions mainly as liver meridian,kidney meridian and spleen meridian.According to the occurrence frequency from high to low,the paired-herbs included Myrrh-Frankincense,Drynaria Fortunei-Chinese Angelica and Rehmanniae Radix Praeparata-Chinese Angelica; and the triplet-herbs included Myrrh-Frankincense-Chinese Angelica,Myrrh-Frankincense-Drynaria Fortunei and Carthamus Tinctorius-Myrrh-Frankincense in turn.Thirteen association rules of drug combinations were obtained through analysis,and the one with the highest confidence was Frankincense-Drynaria FortuneiMyrrh,and the paired-herbs with the highest correlation was Frankincense-Achyranthes Bidentata.Morover,23 core TCM combinations of triplet-herbs were obtained,including Radix Ginseng Rubra-Musk-Pulvis Fellis Suis,Codonopsis Pilosula-Epimedium-Caulis Spatholobi and Atractylodes Macrocephala Koidz-Ligusticum Chuanxiong-Poria Cocos,and 8 groups of core combinations of new prescriptions were extracted out,and 4 new prescriptions were synthesized.Conclusion:The TCM compounds exhibit the drug property mainly as warm and normal; the flavours mainly as sweet,bitter and pungent; the meridian distributions mainly as liver meridian,kidney meridian and spleen meridian; and the pharmacological actions mainly as liver-kidney-regulating,blood-activating and stasis-resolving as well as Qi-replenishing and spleen-invigorating in treatment of ONFH.

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更新日期/Last Update: 2021-12-20